Identification of the rate-limiting step in the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide.
作者信息
O'Leary M H, Kluetz M D
出版信息
J Am Chem Soc. 1970 Oct 7;92(20):6089-90. doi: 10.1021/ja00723a062.
PMID:5459201
Abstract
摘要
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Identification of the rate-limiting step in the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide.鉴定胰凝乳蛋白酶催化N-乙酰-L-色氨酸酰胺水解反应中的限速步骤。
J Am Chem Soc. 1970 Oct 7;92(20):6089-90. doi: 10.1021/ja00723a062.
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The mechanism of the alpha-chymotrypsin and trypsin-catalyzed hydrolysis of amides. Evidence for the participation of the active serine in the amidase activity of trypsin.α-胰凝乳蛋白酶和胰蛋白酶催化酰胺水解的机制。活性丝氨酸参与胰蛋白酶酰胺酶活性的证据。
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Molecular orbital studies of enzyme activity: I: Charge relay system and tetrahedral intermediate in acylation of serine proteinases.酶活性的分子轨道研究：I：丝氨酸蛋白酶酰化反应中的电荷中继系统和四面体中间体。
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