胰岛素、氢化可的松和催乳素对乳腺外植体的一些超微结构影响。
Some ultrastructural effects of insulin, hydrocortisone, and prolactin on mammary gland explants.
作者信息
Mills E S, Topper Y J
出版信息
J Cell Biol. 1970 Feb;44(2):310-28. doi: 10.1083/jcb.44.2.310.
Abstract
The effects of insulin, hydrocortisone, and prolactin on the morphology of explants from midpregnant mouse mammary glands were studied. Insulin promotes the formation of daughter cells within the alveolar epithelium which are ultrastructurally indistinguishable from the parent cells. The addition of hydrocortisone to the medium containing insulin brings the daughter cells to a new, intermediate level of ultrastructural development by effecting an extensive increase of the rough endoplasmic reticulum (RER) throughout the cytoplasm and an increase in the lateral paranuclear Golgi apparatus. When prolactin is added to the insulin-hydrocortisone medium, the daughter cells complete their ultrastructural differentiation. There is a translocation of the RER, Golgi apparatus, and nucleus and the appearance of secretory protein granules within the cytoplasm. There is excellent correlation between the ultrastructural appearance of the alveoli and their capacity to synthesize casein.
摘要
研究了胰岛素、氢化可的松和催乳素对妊娠中期小鼠乳腺外植体形态的影响。胰岛素促进肺泡上皮内子细胞的形成，这些子细胞在超微结构上与亲代细胞无法区分。在含有胰岛素的培养基中添加氢化可的松，通过使整个细胞质中的粗面内质网（RER）大量增加以及核旁高尔基体外侧增加，使子细胞达到超微结构发育的新的中间水平。当将催乳素添加到胰岛素 - 氢化可的松培养基中時，子细胞完成其超微结构分化。RER、高尔基体和细胞核发生移位，细胞质内出现分泌蛋白颗粒。肺泡的超微结构外观与其合成酪蛋白的能力之间存在良好的相关性。
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