Lawrence G, Walker P D
Lancet. 1976 Jan 17;1(7951):125-6. doi: 10.1016/s0140-6736(76)93160-3.
It is suggested that enteritis necroticans occurs in the people of the Highlands of Papua New Guinea because they have low levels of digestive proteases in the intestinal lumen. These low protease levels are the result of a low-protein diet and the presence of heat-stable trypsin inhibitors in sweet potatato, the dietary staple. Low proteolytic activity allows the B toxin of Clostridium welchii type C, which is extremely susceptible to proteolysis, to initiate the disease.
有人认为，坏死性肠炎在巴布亚新几内亚高地人群中出现是因为他们肠腔内消化蛋白酶水平较低。这些低蛋白酶水平是低蛋白饮食以及主食甘薯中存在热稳定胰蛋白酶抑制剂的结果。低蛋白水解活性使得极易被蛋白水解的C型魏氏梭菌的B毒素引发该病。
