Harthon L, Brattsand R
Arzneimittelforschung. 1979;29(12):1859-62.
The esters between nicotinic acid and pentaerythritol (niceritrol, Perycit) or meso-inositol (MIHN) were hydrolyzed by enzymes present in plasma and tissues of man, rat and dog. Human plasma and rat tissues hydrolyzed niceritrol at a higher rate than did MIHN. The reversed relation was found with dog tissue. The ability of niceritrol and MIHN to raise the level of free nicotinic acid of plasma was studied on man, dog and rat and related with their hydrolysis in vitro and the different solubility of the esters. There was a relationship between these properties of the esters and their ability to increase the plasma level of nicotinic acid.
烟酸与季戊四醇（肌醇烟酸酯，心脉乐）或肌醇（肌醇烟酸酯）形成的酯可被人、大鼠和犬的血浆及组织中的酶水解。人血浆和大鼠组织对肌醇烟酸酯的水解速率高于肌醇烟酸酯。在犬组织中发现了相反的关系。在人、犬和大鼠身上研究了肌醇烟酸酯和肌醇烟酸酯提高血浆游离烟酸水平的能力，并将其与它们在体外的水解以及酯的不同溶解度相关联。这些酯的这些特性与其增加血浆烟酸水平的能力之间存在关联。
