Richter W, Kranz D
J Hirnforsch. 1979;20(5):475-505.
The migration has been investigated in 171 embryonic and neonatal rats by means of autoradiographs, after injection of tritiated thymidine from E 18 to P 12 in 4 regions of the brain (Mesoarchicortex, Regio cingularis mesoneocorticalis, Area praecentralis angranularis, Area postcentralis). The migration begins at the third day after the injection. The localization of labeled cells was found in the cortical plate after injection in the early embryonic period and in the L II after injection in the late phasis always at the third day, the speed of migration increases in the course of embryonic development. The migration indicates in all regions an inside-out sequence. Cells from the last division migrates to the surface of the cortical plate. The cortical plate is a transitory element of the brain development. The lamination is possible earlier by means of the distribution pattern of labeled cells than with cytoarchitectonics and also the observation of areas.
通过放射自显影片，在171只胚胎和新生大鼠中研究了迁移情况，在胚胎第18天至出生后第12天，向大脑的4个区域（中旧皮质、扣带回中 neocorticalis区域、中央前无颗粒区、中央后区）注射了氚标记的胸腺嘧啶核苷。迁移在注射后第三天开始。在胚胎早期注射后，标记细胞位于皮质板中，而在后期注射后，总是在第三天位于第二层，迁移速度在胚胎发育过程中增加。在所有区域，迁移都显示出由内向外的顺序。最后分裂的细胞迁移到皮质板表面。皮质板是大脑发育的一个过渡元素。借助标记细胞的分布模式，比通过细胞构筑学以及区域观察更早地实现分层。
