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[雄性无特定病原体(SPF)猫和树鼩三叉神经运动核的个体发育系列的定性和定量检查]

[Qualitative and quantitative examinations of the nucleus motorius n. trigemini in ontogenetic series of male SPF cats and Tupaia belangeri].

作者信息

Brietze K H, Krysewski M

出版信息

J Hirnforsch. 1979;20(5):507-25.

PMID:546981
Abstract

The Nucl. motorius n. trigemini is qualitatively evaluated in Tupaia belangeri and SPF-cats with cyto-, myelo- and fibrilloarchitectonis methods. The criteria for demarcating the Nucl. motorius n. trigemini are also described. The quantitative evaluation was performed on ontogenetic series of 35 male Tupaia belangeri and 47 male SPF-cats. The growth of the fresh volume is described with the logistic growth function: y = (Formula: see text) The Nucl. motorius n. trigemini has bilaterally an ideal fresh volume of 0.80 mm3 in Tupaia belangeri and 3.43 mm3 in SPF-cats. In comparison with the whole brain, the Nucl. motorius n. trigemini shows a delayed development. In Tupaia belangeri, the half life of the fresh volume growth is 67.4 days of ontogenesis compared to 55.7 days of ontogenesis for the whole brain. In SPF-cats, the half life is 109.1 days of ontogenesis compared to 85.5 days of ontogenesis for the whole brain. The number of neurons in the right side of the Ncul. motorius n. trigemini in SPF-cats is described by a sum of exponential functions: y = P1 . eP2.t + P3 . eP4.t + P5. The nucleus reaches its ideal value of 2540 neurons at 85 days of ontogenesis. A perinatal spontaneous loss of neurons is observed in SPF-cats at a comparatively early period between the 39th and 47th day of ontogenesis. The loss is about 25% in comparison to the ideal value. The proof of over-shooting growth with spontaenous neuronal degeneration was demonstrated in SPF-cats. In this model, the exogenous influence of pathogenic origin could be excluded for this perinatal process.

摘要

采用细胞、髓鞘和纤维构筑学方法,对树鼩和无特定病原体猫的三叉神经运动核进行了定性评估。还描述了划分三叉神经运动核的标准。对35只雄性树鼩和47只雄性无特定病原体猫的个体发育系列进行了定量评估。新鲜体积的增长用逻辑增长函数描述:y =(公式:见正文)。树鼩的三叉神经运动核双侧理想新鲜体积为0.80立方毫米,无特定病原体猫为3.43立方毫米。与全脑相比,三叉神经运动核发育延迟。在树鼩中,新鲜体积增长的半衰期为个体发育67.4天,而全脑为个体发育55.7天。在无特定病原体猫中,半衰期为个体发育109.1天,而全脑为个体发育85.5天。无特定病原体猫三叉神经运动核右侧的神经元数量用指数函数之和描述:y = P1.eP2.t + P3.eP4.t + P5。该核在个体发育85天时达到其理想值2540个神经元。在无特定病原体猫中,在个体发育第39天至47天的相对早期观察到围产期神经元自发丢失。与理想值相比,丢失约为25%。在无特定病原体猫中证明了伴有自发神经元变性的过度生长。在该模型中,可以排除这种围产期过程的致病源外源性影响。

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