用色甘酸钠对大鼠被动皮肤过敏反应的研究。I. 抗二硝基苯7S-γ-2抗体引起的皮肤反应
Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. I. Cutaneous reactions induced by an anti-DNP 7S-gamma-2 antibody.
作者信息
Orr T S, Gwilliam J, Cox J S
出版信息
Immunology. 1970 Sep;19(3):469-79.
The 4-hour passive cutaneous anaphylaxis reaction (PCA) in rats induced by rat anti-DNP 7Sγ antibody has been investigated and compared with the rat reagin induced PCA reaction. Time course studies revealed that the PCA reaction was made up of at least two parts, an early immediate reaction which involved mast cell degranulation, was inhibited by disodium cromoglycate and by cyproheptadine and a late reaction unaffected by disodium cromoglycate, by cyproheptadine and by an anti-SRS-A agent, diethyl-carbamazine. The early part of the 7Sγ reaction was found to be comparable to the rat reagin PCA reaction whereas the later part of the 7Sγ reaction does not appear to involve similar pathways or mediators.
对大鼠抗二硝基苯（DNP）7Sγ抗体诱导的大鼠4小时被动皮肤过敏反应（PCA）进行了研究，并与大鼠反应素诱导的PCA反应进行了比较。时间进程研究表明，PCA反应至少由两部分组成，一个早期即刻反应，涉及肥大细胞脱颗粒，可被色甘酸钠和赛庚啶抑制，还有一个晚期反应，不受色甘酸钠、赛庚啶和抗慢反应物质A（SRS-A）药物（二乙氨基甲嗪）的影响。发现7Sγ反应的早期部分与大鼠反应素PCA反应相当，而7Sγ反应的后期部分似乎不涉及类似的途径或介质。
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