硒代和硫代鸟嘌呤 - 铂（II）配合物的合成及其在小鼠体内的抗肿瘤活性。
Synthesis of seleno- and thio-guanine-Pt (II) complexes and their antitumor activity in mice.
作者信息
Maeda M, Abiko N, Sasaki T
出版信息
Nucleic Acids Symp Ser. 1979(6):s31-4.
PMID:547237
Abstract
Selenoguanine- and selenoguanosine-platinum(II) complexes were synthesized, and their atitumor activities against L1210 in mice and against in vitro tissue culture system were studied. These compounds exhibited antitumor activity of medium strength and showed very low toxicity. The effect of the SeG-Pt (II) complex in mice was retained longer than that of the parent compound SeG because the SeG-Pt (II) complex very slowly released SeG into blood.
摘要
合成了硒代鸟嘌呤和硒代鸟苷-铂（II）配合物，并研究了它们对小鼠L1210及体外组织培养系统的抗肿瘤活性。这些化合物表现出中等强度的抗肿瘤活性且毒性极低。硒代鸟嘌呤-铂（II）配合物在小鼠体内的作用比母体化合物硒代鸟嘌呤持续时间更长，因为硒代鸟嘌呤-铂（II）配合物向血液中释放硒代鸟嘌呤的速度非常缓慢。
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