SPC - 703对家兔和大鼠血压以及豚鼠离体心脏的影响。

The influence of SPC-703 on blood pressure in rabbits and rats and on isolated heart of guinea pigs.

作者信息

Matuszek M, Gagało I, Hać E

出版信息

Pol J Pharmacol Pharm. 1979 Sep-Oct;31(5):455-9.

Abstract

New oral hypoglycemic drug, SPC-703, given in doses of 100 and 200 mg/kg iv rised the arterial pressure in the rat. In the experiments in rabbits, a dose of 100 mg/kg iv was without effect, and the dose of 200 mg/kg rised the blood pressure only temporarily. The cumulative doses of SPC-703 given on the Langendorff isolated heart of the guinea pig, significantly increased the contractile force at the dose 135 mg. The mechanism of inotropic effect of the antidiabetic drugs, derivatives of sulfonylurea is discussed.

摘要

新型口服降糖药SPC - 703，静脉注射剂量为100和200毫克/千克时可升高大鼠动脉血压。在兔实验中，静脉注射100毫克/千克剂量无作用，200毫克/千克剂量仅使血压暂时升高。在豚鼠离体Langendorff心脏上给予累积剂量的SPC - 703，在剂量为135毫克时可显著增加收缩力。文中讨论了磺酰脲衍生物类抗糖尿病药物的正性肌力作用机制。

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