Trachte G J, Lefer A M, Aharony D, Smith J B
Prostaglandins. 1979 Dec;18(6):909-14. doi: 10.1016/0090-6980(79)90127-8.
The omega-6 and omega-9 hydroperoxides of arachidonic acid caused dose-dependent constriction of cat coronary arteries in concentrations of 10(-8) to 10(-5) M. Their potency was comparable to that of prostaglandin (PG) E2, and PGF2 alpha and 100 times greater than that of arachidonic acid. The cyclooxygenase inhibitor, meclofenamate markedly reduced constriction caused by the hydroperoxides but potentiated constriction caused by the prostaglandins. The effects of the hydroperoxides were also reduced by indomethacin and dexamethasone but were unaffected by the thromboxane synthetase inhibitor imidazole. Since the hydroperoxides are not substrates for cyclooxygenase, it is suggested that they have a direct effect on the arteries which can be antagonized by anti-inflammatory drugs.
花生四烯酸的ω-6和ω-9氢过氧化物在浓度为10⁻⁸至10⁻⁵M时可引起猫冠状动脉剂量依赖性收缩。它们的效力与前列腺素（PG）E2和PGF2α相当，比花生四烯酸强100倍。环氧化酶抑制剂甲氯芬那酸显著降低了氢过氧化物引起的收缩，但增强了前列腺素引起的收缩。吲哚美辛和地塞米松也降低了氢过氧化物的作用，但血栓素合成酶抑制剂咪唑对其无影响。由于氢过氧化物不是环氧化酶的底物，提示它们对动脉有直接作用，可被抗炎药物拮抗。
