Loubrieu G, Bourin M, Bizière K, Breteau M, Autret A
Toxicol Eur Res. 1979 Jul;2(4):207-10.
Bromide encephalopathies are frequently reported in Northern America and Great Britain. There is no characteristic clinical pattern, the neurological symptoms are multiple, this is readily explained by the diffusion of bromide ions to all regions in the central nervous system. An accurate history (bromide intake, followed by the slow onset of digestive and neuropsychiatric symptoms) as well as an apparent hyperchloremia are of the greatest aid in suggesting the diagnosis. The incidence of this type of intoxication is greater in women over 50. The association of a salt free diet to bromide therapy favors the onset of clinical symptoms because of the competition between bromide and chloride at the choroid plexus and at the renal tubule.
溴中毒性脑病在北美和英国屡有报道。该病没有特征性的临床模式，神经症状多种多样，这很容易用溴离子扩散到中枢神经系统的所有区域来解释。准确的病史（摄入溴化物，随后出现消化系统和神经精神症状的缓慢发作）以及明显的高氯血症对提示诊断最有帮助。这种中毒类型在50岁以上女性中的发病率更高。无盐饮食与溴化物治疗相结合会促使临床症状出现，因为在脉络丛和肾小管处溴化物与氯化物存在竞争。
