Thiery M, De Gezelle H, Van Kets H, Voorhoof L, Verheugen C, Smis B, Gerris J, Derom R, Martens G
Z Geburtshilfe Perinatol. 1979 Dec;183(6):448-52.
A randomized study to evaluate the effect of natural estrogens on the unripe uterine term cervix was conducted. One hundred and five term gravidas were studied, of whom 70 were treated with 180 mg 17 beta-estradiol or 250 mg estriol (treated women) and 35 were treated with gel only (control group). In all subjects the distented Foley catheter used for the instillation was left in situ. Twelve hours after the instillation there was no apparent difference in mean cervical progress between treated women and controls and the rather unexpected degree of cervical ripening is atributed to the intra-uterine balloon catheter. The procedure could not be shown to have any untoward effect on the mother or the fetus.
开展了一项随机研究，以评估天然雌激素对未成熟足月子宫颈的作用。研究了105名足月孕妇，其中70名接受180毫克17β-雌二醇或250毫克雌三醇治疗（治疗组女性），35名仅接受凝胶治疗（对照组）。在所有受试者中，用于滴注的扩张Foley导管留在原位。滴注12小时后，治疗组女性与对照组之间的平均宫颈进展无明显差异，而相当意外的宫颈成熟程度归因于宫内球囊导管。该操作未显示对母亲或胎儿有任何不良影响。
