Marsch W C, Nürnberger F
Z Hautkr. 1979 Dec 15;54(24):1067-72.
The adenoma of the nipple (syn.: erosive adenomatosis, papillary adenoma, florid papillomatosis) is a benign tumour of the major nipple ducts and presents chiefly as an eroded oozing and crusted lesion with serous or sanguineous discharge of the nipple or as an indurated nodule. The lesion can be mistaken clinically for Paget's disease of the nipple. The correct diagnosis, however, can easily be established by an incisional biopsy. Pathohistologically, the tumour displays adenomatous and papillomatous proliferation of the milk sinus epithelium. An outer myoepithelial and inner columnar epithelium layer can mostly be distinguished. Atypical cellular features are lacking. Keratin cysts near the mostly eroded epidermal surface are are additional characteristic signs. The resection of the nipple is the therapy of choice. The adenoma of the nipple is no precancerous condition. A typical case of adenoma of the nipple from a 54 year old woman is presented.
乳头腺瘤(同义词:糜烂性腺瘤病、乳头状腺瘤、 florid乳头瘤病)是主要乳头导管的一种良性肿瘤,主要表现为乳头糜烂、渗液、结痂,伴有浆液性或血性乳头溢液,或表现为硬结性结节。临床上该病变可能被误诊为乳头佩吉特病。然而,通过切开活检很容易做出正确诊断。病理组织学上,肿瘤表现为乳窦上皮的腺瘤样和乳头状增生。大多可区分出外层的肌上皮层和内层的柱状上皮层。缺乏非典型细胞特征。在大多糜烂的表皮表面附近的角质囊肿是额外的特征性表现。乳头切除术是首选治疗方法。乳头腺瘤不是癌前病变。本文展示了一名54岁女性乳头腺瘤的典型病例。