肾病综合征中的血管并发症：与类固醇治疗及促凝血酶原加速生成的关系
Vasculas complications in nephrotic syndrome: relationship to steroid therapy and accelerated thromboplastin generation.
作者信息
Mukherjee A P, Toh B H, Chan G L, Lau K S, White J C
出版信息
Br Med J. 1970 Oct 31;4(5730):273-6. doi: 10.1136/bmj.4.5730.273.
Abstract
Arterial thrombosis and renal vein thrombosis occurred in two men and one woman, respectively, treated with steroids for the nephrotic syndrome. Raised serum cholesterol occurred in one patient only. Though bleeding, clotting, and prothrombin times, as well as the platelet counts, were normal, the rate of thromboplastin generation was increased in all three patients. Adding heparin to the plasma of one patient slowed the rate, and suggested that the raised rate could be due to removal or suppression of such normal circulating coagulation inhibitors. The thromboplastin generation test seems to be useful in diagnosing and managing such hypercoagulable states, and may help in further investigations of their causes.
摘要
两名男性和一名女性在接受类固醇治疗肾病综合征时分别发生了动脉血栓形成和肾静脉血栓形成。仅一名患者出现血清胆固醇升高。尽管出血时间、凝血时间、凝血酶原时间以及血小板计数均正常，但所有三名患者的凝血活酶生成速率均升高。在一名患者的血浆中加入肝素后，速率减慢，这表明升高的速率可能是由于正常循环凝血抑制剂的去除或抑制所致。凝血活酶生成试验似乎有助于诊断和处理此类高凝状态，并可能有助于进一步研究其病因。
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