Reiss E, Canterbury J M, Bercovitz M A, Kaplan E L
J Clin Invest. 1970 Nov;49(11):2146-9. doi: 10.1172/JCI106432.
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
在人体中，口服1克磷会导致血清免疫可测定甲状旁腺激素（PTH）浓度升高60 - 125%。PTH在1小时内达到峰值水平，并在2小时内恢复到基线水平。PTH的这种升高似乎是由总钙和离子钙非常小的下降引发的，并且通过钙输注消除。血清磷与PTH之间没有相关性。这些实验表明，口服磷会启动一个由钙介导的PTH分泌控制系统，并且该系统在人体中非常敏感地起作用。
