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1
Purification and amino acid sequence of melanocyte-stimulating hormone from the dogfish Squalus acanthias.白斑角鲨（Squalus acanthias）中促黑素细胞激素的纯化及氨基酸序列
Biochem J. 1970 Aug;118(5):713-8. doi: 10.1042/bj1180713.
2
Structural studies of alpha-melanocyte-stimulating hormone and a novel beta-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.对来自角鲨（Squalus acanthias）垂体神经中间叶的α-黑素细胞刺激素和一种新型β-黑素细胞刺激素的结构研究。
Biochem J. 1974 Aug;141(2):439-44. doi: 10.1042/bj1410439.
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The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.对白斑角鲨垂体远侧部促肾上腺皮质激素及神经中间叶促肾上腺皮质激素样中间叶肽的分离与氨基酸序列分析
Biochem J. 1974 Aug;141(2):427-37. doi: 10.1042/bj1410427.
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Isolation and structural characterization of peptides related to alpha- and gamma-melanocyte-stimulating hormone (MSH) from the frog brain.从蛙脑中分离并鉴定与α-和γ-黑素细胞刺激素（MSH）相关的肽段及其结构特征。
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Identification of an MRAP-independent melanocortin-2 receptor: functional expression of the cartilaginous fish, Callorhinchus milii, melanocortin-2 receptor in CHO cells.鉴定一种不依赖于黑色素皮质激素受体蛋白的黑色素皮质激素-2 受体：软骨鱼，星鲨，黑色素皮质激素-2 受体在 CHO 细胞中的功能表达。
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4
Structural studies of alpha-melanocyte-stimulating hormone and a novel beta-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.对来自角鲨（Squalus acanthias）垂体神经中间叶的α-黑素细胞刺激素和一种新型β-黑素细胞刺激素的结构研究。
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5
The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.对白斑角鲨垂体远侧部促肾上腺皮质激素及神经中间叶促肾上腺皮质激素样中间叶肽的分离与氨基酸序列分析
Biochem J. 1974 Aug;141(2):427-37. doi: 10.1042/bj1410427.
6
Metabolism of two adrenocorticotrophin analogues in the intestine of the rat.两种促肾上腺皮质激素类似物在大鼠肠道中的代谢
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7
Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin.人促肾上腺皮质激素1 - 20氨基酸序列的确认。
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8
Complete amino acid analysis of peptides and proteins after hydrolysis by a mixture of sepharose-bound peptidases.用琼脂糖结合肽酶混合物水解后对肽和蛋白质进行完整氨基酸分析。
Biochem J. 1972 Sep;129(3):695-701. doi: 10.1042/bj1290695.
9
Localization of melanotropin-like peptides in the central nervous system of two insect species, the migratory locust, Locusta migratoria, and the fleshfly, Sarcophaga bullata.促黑素样肽在两种昆虫——飞蝗（Locusta migratoria）和麻蝇（Sarcophaga bullata）中枢神经系统中的定位。
Cell Tissue Res. 1987 Apr;248(1):25-31. doi: 10.1007/BF01239958.

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白斑角鲨（Squalus acanthias）中促黑素细胞激素的纯化及氨基酸序列

Purification and amino acid sequence of melanocyte-stimulating hormone from the dogfish Squalus acanthias.

作者信息

Lowry P J, Chadwick A

出版信息

Biochem J. 1970 Aug;118(5):713-8. doi: 10.1042/bj1180713.

DOI:10.1042/bj1180713
PMID:5476715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1179279/
Abstract

A melanocyte-stimulating hormone (MSH) was isolated by gel filtration and ion-exchange chromatography from extracts of the pituitary glands of dogfish. Sequence studies were carried out on the hormone and its enzymically and chemically cleaved fragments. The sequence of the hormone, Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met, shows that ten of its 11 residues are the same as ten of the 13 residues of mammalian alpha-MSH. About half of its molecules have the carboxyl group at the C-terminus free and about half are amidated; about a fifth have an extra tyrosine residue on the N-terminus, thereby making 11 residues the same as in mammalian alpha-MSH. Unlike the mammalian hormone, however, none of it was found to be N-acetylated.

摘要

通过凝胶过滤和离子交换色谱法从角鲨的垂体提取物中分离出一种促黑素细胞激素（MSH）。对该激素及其经酶切和化学裂解的片段进行了序列研究。该激素的序列为Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met，表明其11个残基中的10个与哺乳动物α-MSH的13个残基中的10个相同。其分子约一半的C末端羧基是游离的，约一半是酰胺化的；约五分之一在N末端有一个额外的酪氨酸残基，从而使11个残基与哺乳动物α-MSH中的相同。然而，与哺乳动物激素不同的是，未发现其有N-乙酰化。