Combard A, Vendrely R
Biochem J. 1970 Aug;118(5):875-81. doi: 10.1042/bj1180875.
The mechanism of nucleohistone degradation in calf thymus chromatin during autolysis of the latter involves a release of lysine-rich histone fractions, followed by degradation of the thus-exposed DNA portions; the latter portions are richest in adenine-thymine sequences. After this degradation process, residual nucleohistone fragments of low molecular weight (10(5)) remain. Their chemical composition is special, in that the DNA contains a larger proportion of guanine-cytosine sequences than does the initial DNA and it is combined with arginine-rich histones.
小牛胸腺染色质自溶过程中核组蛋白降解的机制包括富含赖氨酸的组蛋白组分的释放,随后是如此暴露的DNA部分的降解;后一部分富含腺嘌呤 - 胸腺嘧啶序列。在这个降解过程之后,留下了低分子量(10⁵)的残留核组蛋白片段。它们的化学组成很特殊,因为与初始DNA相比,DNA中鸟嘌呤 - 胞嘧啶序列的比例更大,并且它与富含精氨酸的组蛋白结合。