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抗链球菌溶血素O抗体的免疫球蛋白分析。

Immunoglobulin analysis of anti-streptolysin-O antibody.

作者信息

Sonozaki H, Takizawa S, Torisu M

出版信息

Clin Exp Immunol. 1970 Oct;7(4):519-31.

PMID:5477266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712852/
Abstract

The immunoglobulin characteristics of human serum ASLO antibody were examined using Sephadex gel filtration column chromatography. IgM associated ASLO antibody was found in certain sera. IgM ASLO antibody appeared in sera from individuals suspected of having had their initial streptococcal infection, and was detected only in sera from children having ASLO titres below 2 Todd unit (T.u.) at first, and having acquired titres of around 333 T.u. after 3 months. IgM ASLO antibody was never found in sera from children who were not at the initial streptococcal infection stage. In addition IgM ASLO antibody was not detected in the sera of children having ASLO titres of over 500 units, even if they were at the initial streptococcal infection stage. No adult sera were shown to have IgM ASLO antibody regardless of their ASLO titres.

摘要

采用葡聚糖凝胶过滤柱层析法检测人血清抗链球菌溶血素O(ASLO)抗体的免疫球蛋白特性。在某些血清中发现了与IgM相关的ASLO抗体。IgM ASLO抗体出现在疑似初次感染链球菌的个体血清中,最初仅在抗链球菌溶血素O效价低于2托德单位(T.u.)的儿童血清中检测到,3个月后效价升至约333 T.u.。在未处于初次链球菌感染阶段的儿童血清中从未发现IgM ASLO抗体。此外,即使处于初次链球菌感染阶段,抗链球菌溶血素O效价超过500单位的儿童血清中也未检测到IgM ASLO抗体。无论成人血清的抗链球菌溶血素O效价如何,均未显示有IgM ASLO抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2f0/1712852/da834878e35f/clinexpimmunol00383-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2f0/1712852/da834878e35f/clinexpimmunol00383-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2f0/1712852/da834878e35f/clinexpimmunol00383-0086-a.jpg

相似文献

1
Immunoglobulin analysis of anti-streptolysin-O antibody.抗链球菌溶血素O抗体的免疫球蛋白分析。
Clin Exp Immunol. 1970 Oct;7(4):519-31.
2
[Antistreptolysin titer and serum concentration of gamma G, gamma A, and gamma M immunoglobulins].[抗链球菌溶血素效价以及γG、γA和γM免疫球蛋白的血清浓度]
Arch Hyg Bakteriol. 1969 Apr;153(2):173-5.
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[Human immunoglobulins. I. The antibacterial and antitoxic spectrum of normal human immunoglobulins].[人免疫球蛋白。I. 正常人免疫球蛋白的抗菌和抗毒谱]
Arch Roum Pathol Exp Microbiol. 1968 Dec;27(4):809-18.
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[Behavior of "hyperimmune globulins" in the course of "streptococcal diseases"].["超免疫球蛋白"在"链球菌疾病"病程中的行为]
Minerva Pediatr. 1971 Apr 21;23(16):723-4.
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[Some aspects of antistreptococcal immunological reactivity in aged subjects].[老年受试者抗链球菌免疫反应性的某些方面]
Arch Roum Pathol Exp Microbiol. 1969 Jun-Sep;28(2):361-72.
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The effect of beta-lipoprotein on antistreptolysin-O antibody titers.β-脂蛋白对抗链球菌溶血素O抗体效价的影响。
Jpn J Microbiol. 1973 Jul;17(4):257-64. doi: 10.1111/j.1348-0421.1973.tb00771.x.
7
M components with antibody activity. Anti-smooth muscle, anti-thyroglobulin and anti-streptolysin-O activity in five M component sera.具有抗体活性的M成分。五种M成分血清中的抗平滑肌、抗甲状腺球蛋白和抗链球菌溶血素O活性。
Ann Clin Res. 1971 Apr;3(2):86-97.
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[Case of anti-streptolysin O activity in M-like protein detected by preparative electrofocusing].[通过制备性电聚焦检测 M 样蛋白中抗链球菌溶血素 O 活性的病例]
Rinsho Byori. 1983 Oct;31(10):1099-103.
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[Determination of the anti-O-streptolysin titer in a school population of the March district: use of the rapid method of Dean and Webb and evaluation of positivity].[三月区某学校人群抗O-链球菌溶血素效价的测定:迪安和韦伯快速法的应用及阳性率评估]
Quad Sclavo Diagn. 1979 Mar;15(1):74-7.
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Anti-streptolysin O titer, fifty-five years after Todd: a reappraisal of its clinical significance.
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引用本文的文献

1
Predominance of immunoglobulin G sub-class 3 among the complement-fixing antibodies to streptococcal M-associated protein.针对链球菌M相关蛋白的补体结合抗体中免疫球蛋白G 3亚类占优势。
Clin Exp Immunol. 1979 Aug;37(2):247-58.

本文引用的文献

1
Determination of C-reactive protein in the blood as a measure of the activity of the disease process in acute rheumatic fever.测定血液中的C反应蛋白,以此作为急性风湿热疾病进程活动度的一项指标。
Am J Med. 1950 Apr;8(4):445-55. doi: 10.1016/0002-9343(50)90226-9.
2
SEPARATION OF RHEUMATOID FACTORS AND ANTISTREPTOLYSINS BY GEL FILTRATION AND PREPARATIVE ELECTROPHORESIS.
Acta Pathol Microbiol Scand. 1964;61:127-40. doi: 10.1111/apm.1964.61.1.127.
3
[A micro-method of immuno-electrophoresis].[免疫电泳的微量方法]
Int Arch Allergy Appl Immunol. 1955;7(2):103-10.
4
Antibody heterogeneity and serological reactions.抗体异质性与血清学反应。
Bacteriol Rev. 1967 Jun;31(2):157-74. doi: 10.1128/br.31.2.157-174.1967.