Roger P, Mauriac L, Kern A M, Schmitt B, Saurel J, Brun G
Ann Endocrinol (Paris). 1979;40(6):571-2.
The authors present the case of a young hirsute woman of 28 years old. Urinary 17 KS were very increased without DHA, but with androsterone, etiocholanolone and 11 oxy 17 Ketosteroids. Androstenedione and testosterone plasmatic levels were very high and per operative selective ovarian vein catheterization showed a direct production of these potent androgens. In vitro study of the tumor allowed to obtain same results. Light and electron microscopic study showed a Leydig cell tumor of left ovary.
作者报告了一名28岁多毛年轻女性的病例。尿17-酮类固醇在无双氢雄酮时显著升高,但有雄酮、表雄酮和11-氧代-17-酮类固醇。血浆雄烯二酮和睾酮水平非常高,术中选择性卵巢静脉插管显示这些强效雄激素直接产生。对肿瘤的体外研究也得到了相同结果。光镜和电镜研究显示为左卵巢间质细胞瘤。