Mitchell D N, Rees R J
Postgrad Med J. 1970 Aug;46(538):510-4. doi: 10.1136/pgmj.46.538.510.
The results of a controlled experiment in which an attempt was made to transmit sarcoidosis by inoculation of sarcoid and non-sarcoid lymph node homogenates into the footpads of normal and immunologically deficient mice, are reported. The and changes in the footpads were assessed microscopically. A substantial proportion of the footpads of mice receiving sarcoid homogenate showed the histological characteristics typical of sarcoidosis in man and evolved fully only after a period of 6-8 months following inoculation. Moreover, positive Kveim tests were confined to a proportion of those mice given sarcoid homogenates and were all associated with a sarcoid granuloma in the footpad. Conversely, the inflammatory lesions seen in the histology of the footpads of mice inoculated with non-sarcoid homogenate were no longer apparent in the histology and Kveim tests in all mice given non-sarcoid homogenate were negative.
报告了一项对照实验的结果，该实验试图通过将结节病和非结节病淋巴结匀浆接种到正常和免疫缺陷小鼠的足垫中来传播结节病。通过显微镜评估足垫的 和 变化。接受结节病匀浆的小鼠中，相当一部分足垫显示出人类结节病典型的组织学特征，并且仅在接种后6-8个月的一段时间后才完全发展。此外，阳性Kveim试验仅限于接受结节病匀浆的部分小鼠，并且都与足垫中的结节病肉芽肿相关。相反，接种非结节病匀浆的小鼠足垫组织学中所见的炎性病变在 组织学中不再明显，并且所有接受非结节病匀浆的小鼠的Kveim试验均为阴性。
