去甲肾上腺素在情感障碍中的作用（作者译）
[The role of norepinephrine in affective disorders (author's transl)].
作者信息
Puech A J, Lecrubier Y, Simon P
出版信息
Encephale. 1979;5(5 Suppl):507-19.
The role of norepinephrine in affective disorders is supported by the following data. There is a decrease of activity of the noradrenergic system in depressive patients, evaluated by: --a decrease of the metabolism of noradrenaline; --an hyperreactivity of adrenergic receptors; --a decrease of the secretion of some hormones (melatonine, renine, corticosteroides) the liberation of which is mediated by stimulation of adrenoreceptors. The well recognized antidepressant drugs are able to activate by different mechanisms the noradrenergic system. Reciprocally, drugs well known to stimulate noradrenergic system are able to increase mood. Complementarily, antimaniac drugs are adrenolytic and adrenolytic drugs are antimaniac and depressogenic.
以下数据支持去甲肾上腺素在情感障碍中的作用。通过以下方面评估发现，抑郁症患者去甲肾上腺素能系统活性降低：——去甲肾上腺素代谢减少；——肾上腺素能受体反应性增强；——某些激素（褪黑素、肾素、皮质类固醇）分泌减少，这些激素的释放由肾上腺素能受体刺激介导。众所周知的抗抑郁药物能够通过不同机制激活去甲肾上腺素能系统。相反，已知刺激去甲肾上腺素能系统的药物能够改善情绪。此外，抗躁狂药物具有抗肾上腺素能作用，而抗肾上腺素能药物具有抗躁狂和致抑郁作用。
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