脂肪生成的调节。新孵化雏鸡肝脏中脂肪酸合成在体内和体外的刺激作用。
Regulation of lipogenesis. Stimulation of fatty acid synthesis in vivo and in vitro in the liver of the newly hatched chick.
作者信息
Goodridge A G
出版信息
Biochem J. 1970 Jun;118(2):259-63. doi: 10.1042/bj1180259.
Abstract
- A single glucose meal stimulated the incorporation of acetate into fatty acids in liver slices. If the glucose was added in vitro, it had no effect. Fructose and glycerol in vitro markedly stimulated fatty acid synthesis from acetate. Fructose and glycerol probably by-passed a rate-controlling reaction between glucose and triose phosphate. This reaction may have been stimulated by glucose administered in vivo. 2. The stimulation of fatty acid synthesis caused by fructose did not require the synthesis of enzyme, thus indicating that fatty acid-synthesizing enzymes were present in a latent form in the livers from unfed chicks.
摘要
- 单次给予葡萄糖餐可刺激肝切片中乙酸盐掺入脂肪酸。若在体外添加葡萄糖，则无此作用。体外的果糖和甘油可显著刺激由乙酸盐合成脂肪酸。果糖和甘油可能绕过了葡萄糖与磷酸丙糖之间的一个限速反应。该反应可能已被体内给予的葡萄糖所刺激。2. 果糖引起的脂肪酸合成刺激并不需要酶的合成，因此表明未喂食雏鸡的肝脏中脂肪酸合成酶以潜在形式存在。
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本文引用的文献
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EFFECT OF ACTINOMYCIN AND INSULIN ON THE METABOLISM OF ISOLATED RAT DIAPHRAGM.放线菌素和胰岛素对大鼠离体膈肌代谢的影响。
Biochim Biophys Acta. 1964 Oct 16;91:248-56. doi: 10.1016/0926-6550(64)90248-8.
2
On the origin of unsaturated fatty acids in clostridia.梭菌中不饱和脂肪酸的起源
J Biol Chem. 1961 Oct;236:2596-601.
3
Studies on the mechanism of fatty acid synthesis. IV. Biosynthesis of long-chain fatty acids in a reconstructed system of soluble enzymes from chicken liver.脂肪酸合成机制的研究。IV. 鸡肝可溶性酶重构系统中长链脂肪酸的生物合成。
Biochim Biophys Acta. 1957 Aug;25(2):303-10. doi: 10.1016/0006-3002(57)90473-0.
4
[On the synthesis product of fatty acid synthetase from the livers of different vertebrates].
Hoppe Seylers Z Physiol Chem. 1969 Apr;350(4):407-10.
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Conversion of[U-14C]glucose into carbon dioxide, glycogen, cholesterol and fatty acids in liver slices from embryonic and growing chicks.[U-14C]葡萄糖在胚胎期和生长期雏鸡肝脏切片中转化为二氧化碳、糖原、胆固醇和脂肪酸的过程。
Biochem J. 1968 Jul;108(4):655-61. doi: 10.1042/bj1080655.
6
Fructose metabolism. I. The fructose metabolic pathway.
Am J Clin Nutr. 1968 Mar;21(3):245-9. doi: 10.1093/ajcn/21.3.245.
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