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2
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5
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J Pharmacol Exp Ther. 1970 Apr;172(2):289-96.
6
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Br J Pharmacol. 1973 Aug;48(4):609-11. doi: 10.1111/j.1476-5381.1973.tb08247.x.
7
Effects of McN-A-343 and DMPP on the uptake and release of 3 H-noradrenaline by guinea-pig atria.McN - A - 343和二甲基苯基哌嗪对豚鼠心房摄取和释放3H - 去甲肾上腺素的影响。
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[Effect of 2-amino-4,5,6,7-tetrahydro-5-propyl-thiazole(5,4-c)pyridine, an antihypertensive and sedative substance, on the noradrenaline storage in the heart of guinea pigs].
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10
Effect of tyramine on isolated guinea-pig atria in relation to their noradrenaline stores.酪胺对豚鼠离体心房的作用及其去甲肾上腺素储备的关系。
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2
Dependence of -adrenoceptor mediated mechanical effects on the glycogen concentration in the rabbit isolated small intestine.β-肾上腺素能受体介导的机械效应与家兔离体小肠糖原浓度的关系。
Br J Pharmacol. 1972 Jun;45(2):378-81. doi: 10.1111/j.1476-5381.1972.tb08093.x.
3
Myocardial and circulatory effects of E. coli endotoxin; modification of responses to catecholamines.大肠杆菌内毒素对心肌和循环系统的影响；对儿茶酚胺反应的改变。
Br J Pharmacol. 1973 Jan;47(1):12-25. doi: 10.1111/j.1476-5381.1973.tb08154.x.
4
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本文引用的文献

1
Effect of lethal doses of bacterial endotoxin (E. coli) on sympathetic neurohormones in the rabbit.致死剂量的细菌内毒素（大肠杆菌）对家兔交感神经激素的影响。
Am J Physiol. 1960 Jun;198:1307-11. doi: 10.1152/ajplegacy.1960.198.6.1307.
2
[THE EFFECT OF DRUGS ON THE ELIMINATION OF NORADRENALIN FROM PERFUSION FLUID AND NORADRENALIN UPTAKE IN THE ISOLATED HEART].[药物对灌注液中去甲肾上腺素清除及离体心脏摄取去甲肾上腺素的影响]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 Jul 28;247:469-92. doi: 10.1007/BF00329896.
3
Influence of guanethidine on the catecholamine depleting effects of tyramine in the rat heart.
J Pharm Pharmacol. 1963 Feb;15:152. doi: 10.1111/j.2042-7158.1963.tb12761.x.
4
The fate of H3-norepinephrine in animals.动物体内H3-去甲肾上腺素的命运
J Pharmacol Exp Ther. 1961 May;132:193-201.
5
The action of sympathomimetic amines in animals treated with reserpine.交感神经胺在接受利血平治疗的动物体内的作用。
J Physiol. 1958 Dec 4;144(2):314-36. doi: 10.1113/jphysiol.1958.sp006104.
6
Investigations on the role of the central nervous system in shock produced by endotoxin from gram-negative microorganisms.
J Lab Clin Med. 1956 Nov;48(5):661-72.
7
Endotoxin shock in the subhuman primate. I. Hemodynamic and biochemical changes.
Arch Surg. 1969 Jul;99(1):107-12. doi: 10.1001/archsurg.1969.01340130109022.
8
Effect of various procedures on the repletion of cardiac catecholamine stores after tyramine.
J Pharmacol Exp Ther. 1965 Oct;150(1):41-5.

去甲肾上腺素和酪胺对内毒素处理的豚鼠离体心房肌的作用。

Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs.

作者信息

Bhagat B, Cavanagh D, Merrild B N, Rana M W, Rao P S

出版信息

Br J Pharmacol. 1970 Aug;39(4):688-95. doi: 10.1111/j.1476-5381.1970.tb09894.x.

DOI:10.1111/j.1476-5381.1970.tb09894.x
PMID:5485145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702735/
Abstract
  1. Isolated left-atrial strips of guinea-pigs were driven electrically at a constant rate and log-concentration curves were determined for the positive inotropic effect of noradrenaline and tyramine.2. The atrial tissue from endotoxin-treated animals had a reduced sensitivity to noradrenaline and tyramine.3. After endotoxin, the sensitizing effect of cocaine on the response to noradrenaline was normal but accumulation of (3)H-noradrenaline in nerve terminals was markedly reduced.4. Atrial tissue of endotoxin-treated guinea-pigs responded normally to stretch.
摘要

  1. 以恒定速率对豚鼠离体左心房条进行电驱动，并测定去甲肾上腺素和酪胺正性肌力作用的对数浓度曲线。

  2. 内毒素处理动物的心房组织对去甲肾上腺素和酪胺的敏感性降低。

  3. 内毒素处理后，可卡因对去甲肾上腺素反应的致敏作用正常，但神经末梢中（3）H-去甲肾上腺素的蓄积明显减少。

  4. 内毒素处理的豚鼠心房组织对拉伸反应正常。