去甲肾上腺素和酪胺对内毒素处理的豚鼠离体心房肌的作用。
Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs.
作者信息
Bhagat B, Cavanagh D, Merrild B N, Rana M W, Rao P S
出版信息
Br J Pharmacol. 1970 Aug;39(4):688-95. doi: 10.1111/j.1476-5381.1970.tb09894.x.
Abstract
- Isolated left-atrial strips of guinea-pigs were driven electrically at a constant rate and log-concentration curves were determined for the positive inotropic effect of noradrenaline and tyramine.2. The atrial tissue from endotoxin-treated animals had a reduced sensitivity to noradrenaline and tyramine.3. After endotoxin, the sensitizing effect of cocaine on the response to noradrenaline was normal but accumulation of (3)H-noradrenaline in nerve terminals was markedly reduced.4. Atrial tissue of endotoxin-treated guinea-pigs responded normally to stretch.
摘要
以恒定速率对豚鼠离体左心房条进行电驱动，并测定去甲肾上腺素和酪胺正性肌力作用的对数浓度曲线。
内毒素处理动物的心房组织对去甲肾上腺素和酪胺的敏感性降低。
内毒素处理后，可卡因对去甲肾上腺素反应的致敏作用正常，但神经末梢中（3）H-去甲肾上腺素的蓄积明显减少。
内毒素处理的豚鼠心房组织对拉伸反应正常。
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