用对氧磷和双复磷处理的大鼠大脑中的乙酰胆碱含量。
Acetylcholine content in the brain of rats treated with paraoxon and obidoxime.
作者信息
Milosević M P
出版信息
Br J Pharmacol. 1970 Aug;39(4):732-7. doi: 10.1111/j.1476-5381.1970.tb09899.x.
Abstract
- The effect of obidoxime on the rise in brain acetylcholine caused by the anticholinesterase paraoxon was studied in the rat.2. In animals poisoned with a sublethal dose of paraoxon and thereafter treated with obidoxime the levels of both "free" and total brain acetylcholine were practically the same as those in rats injected with paraoxon only.3. After poisoning with doses of paraoxon which are lethal unless an oxime is also given, the total acetylcholine in the brain of obidoxime-protected rats continued to accumulate, reaching a peak 2 h after injection of paraoxon. At this time no signs of central effects such as convulsions or tremor were seen.4. Atropine, given 30 min before paraoxon, markedly reduced the rise in total brain acetylcholine seen when the anticholinesterase is given alone.5. In rats pretreated with atropine and obidoxime excessive doses of paraoxon which are lethal in the absence of the antidotes produced a rise in total brain acetylcholine which was directly proportional to the dose of paraoxon administered.
摘要
在大鼠身上研究了双复磷对由抗胆碱酯酶对氧磷引起的脑乙酰胆碱升高的影响。
用亚致死剂量的对氧磷中毒的动物，随后用双复磷治疗，“游离”和脑总乙酰胆碱水平实际上与仅注射对氧磷的大鼠相同。
在用除非同时给予肟否则致死剂量的对氧磷中毒后，双复磷保护的大鼠脑中的总乙酰胆碱继续积累，在注射对氧磷后2小时达到峰值。此时未观察到惊厥或震颤等中枢效应的迹象。
在对氧磷前30分钟给予阿托品，显著降低了单独给予抗胆碱酯酶时脑总乙酰胆碱的升高。
在预先用阿托品和双复磷处理的大鼠中，在没有解毒剂的情况下致死的过量对氧磷导致脑总乙酰胆碱升高，这与给予的对氧磷剂量成正比。
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