蛇毒抗栓酶对家兔网状内皮系统活性的影响。
The effect of Arvin on reticuloendothelial activity in rabbits.
作者信息
Ashford A, Bunn D R
出版信息
Br J Pharmacol. 1970 Sep;40(1):37-44. doi: 10.1111/j.1476-5381.1970.tb10608.x.
Abstract
- Arvin stimulated the reticulo-endothelial uptake of colloidal carbon in rabbits. The onset of effect after intravenous administration was immediate and the minimum stimulant dose by this route was very low-0.05 unit/kg (0.1 mug protein/kg).2. Carbon opsonized in vitro with serum taken 4 h after an intravenous injection of Arvin was cleared more rapidly than carbon treated with control serum. Serum collected 10 min after Arvin did not promote carbon uptake.3. Reticulo-endothelial block with Thorotrast or excess carbon did not prevent the stimulant effect of Arvin but prevented the stimulant effect of opsonization with 4 h serum.4. The reticulo-endothelial stimulant effect of Arvin appears to be unrelated to its coagulant action on fibrinogen. The mechanism may involve a direct action on phagocytic cells and an effect on colloidal particles via serum opsonins.
摘要
阿文能刺激家兔网状内皮系统对胶体碳的摄取。静脉注射后起效迅速，该途径的最小刺激剂量非常低——0.05单位/千克（0.1微克蛋白质/千克）。
静脉注射阿文4小时后采集的血清在体外调理的碳比用对照血清处理的碳清除得更快。阿文注射10分钟后采集的血清不能促进碳的摄取。
用钍造影剂或过量碳阻断网状内皮系统并不能阻止阿文的刺激作用，但能阻止用4小时血清进行调理的刺激作用。
阿文的网状内皮刺激作用似乎与其对纤维蛋白原的凝血作用无关。其机制可能涉及对吞噬细胞的直接作用以及通过血清调理素对胶体颗粒的作用。
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