血清胆碱酯酶的温度活性关系
The temperature activity relationships of serum cholinesterases.
作者信息
King J, Morgan H G
出版信息
J Clin Pathol. 1970 Nov;23(8):730-2. doi: 10.1136/jcp.23.8.730.
Abstract
A study has been made of the temperature activity relationships of the serum cholinesterase variants differentiated by means of dibucaine and fluoride inhibition. Using benzoylcholine as substrate, there is a characteristic temperature activity curve for each phenotype, and, for those most sensitive to succinyldicholine, this differs radically from that of the normal enzyme.A true index of serum cholinesterase activity is obtained only at 37 degrees C, as at other temperatures various assumptions and correction factors have to be made, and the results could be misleading.
摘要
一项关于通过丁卡因和氟化物抑制作用区分的血清胆碱酯酶变体的温度活性关系的研究已经展开。以苯甲酰胆碱作为底物，每种表型都有一条特征性的温度活性曲线，并且，对于那些对琥珀酰胆碱最为敏感的表型，其曲线与正常酶的曲线截然不同。只有在37摄氏度时才能获得血清胆碱酯酶活性的真实指标，因为在其他温度下必须做出各种假设和校正因子，其结果可能会产生误导。
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The temperature activity relationships of serum cholinesterases.血清胆碱酯酶的温度活性关系
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引用本文的文献
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Abnormal enzyme phenotype (E1a E1f): normal response to succinylcholine.异常酶表型（E1a E1f）：对琥珀酰胆碱的正常反应。
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本文引用的文献
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The pseudocholinesterase variants. Esterase levels and dibucaine numbers in families selected through suxamethonium sensitive individuals.假性胆碱酯酶变异体。通过琥珀酰胆碱敏感个体选择的家庭中的酯酶水平和丁卡因值。
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The action of normal and atypical cholinesterase of human serum upon a series of esters of choline.人血清中正常及非典型胆碱酯酶对一系列胆碱酯的作用。
Can J Biochem Physiol. 1960 Jun;38:545-51.
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Differential inhibition of human serum cholinesterase with fluoride: recognition of two new phenotypes.氟化物对人血清胆碱酯酶的差异抑制作用：两种新表型的识别。
Nature. 1961 Jul 29;191:496-8. doi: 10.1038/191496a0.
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A method for the detection of atypical forms of human serum cholinesterase; determination of dibucaine numbers.一种检测人血清胆碱酯酶非典型形式的方法；地布卡因值的测定。
Can J Biochem Physiol. 1957 Jun;35(6):339-46. doi: 10.1139/y57-041.
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A comparison of optical and manometric methods for the assay of human serum cholinesterase.用于测定人血清胆碱酯酶的光学方法与测压法的比较。
Can J Biochem Physiol. 1955 Jul;33(4):568-74.
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