Daniel M T, Flandrin G, Bernard J
Nouv Rev Fr Hematol. 1975 May-Jun;15(3):319-32.
A case of acute Mast-cell leukemia was studied. A 39 years old female presenting with a brief history of abdominal pain and attacks of flushing; peripheral blood and bone marrow contained up to 60% of poorly differentiated blasts with clumping of deep purpule granules. Peroxydase reaction stains were negative, chloroacetate esterase were strongly positive. Toluidine blue revealed metachromatic stain. Histamine content of the cells was highly greater than normal but nos heparinoid activity could be demonstrated. These abnormal mast-cells have been investigated with the electron microscope; only the dense particular type of granule substructure was found, without any lamellae component. The cells were temptatively classified as "immature" mast-cell. The disease was interpretated as an acute leukemic variety of systemic mastocytosis.
对一例急性肥大细胞白血病进行了研究。一名39岁女性，有短暂腹痛和潮红发作史；外周血和骨髓中高达60%为低分化母细胞，伴有深紫色颗粒聚集。过氧化物酶反应染色阴性，氯乙酸酯酶强阳性。甲苯胺蓝显示异染性染色。细胞组胺含量远高于正常，但未显示类肝素活性。用电子显微镜对这些异常肥大细胞进行了研究；仅发现致密特殊类型的颗粒亚结构，无任何板层成分。这些细胞暂被分类为“不成熟”肥大细胞。该疾病被解释为系统性肥大细胞增多症的急性白血病变种。
