类固醇的微生物芳构化生成马萘雌酮。
Microbial aromatization of steroids into equilin.
作者信息
Sehgal S N, Vézina C
出版信息
Appl Microbiol. 1970 Dec;20(6):875-9. doi: 10.1128/am.20.6.875-879.1970.
Abstract
This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.
摘要
本报告描述了用红色诺卡氏菌将19-羟基雄甾-4,7-二烯-3,17-二酮生物转化为马萘雌酮的过程。通过对菌株进行诱变以及对培养基和条件的改进，对于1克/升的底物浓度，生物转化产率可提高至40%的马萘雌酮。文中还报道了雄烯系列的其他几种19-羟基和19-去甲底物的芳构化反应，并讨论了底物分子的各种取代基对芳构化反应的影响。
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