Diekmann B, Klessen B, Kraushaar J, Huth F
Z Lymphol. 1979 Dec;3(2):63-73.
Axillary lymph vessels of 94 autopsy cases (42 female, 52 male) have been investigated histologically in serial slices. Total diameter of the lymph vessels, vascular wall diameter, diameter of the medial connective tissue, finally that one of the artificial tissue spaces were measured in almost 8000 single measurements. The mean values of counts for the different vascular wall components were assessed statistically with the aid of a computer. By reason of the enormous individual variation of the number and the size in lymph vessel system a direct comparison of the measurement data from the different wall components was impossible. Therefore, the ratio of connective tissue to smooth muscle within the vascular media was regarded as a significant parameter for the development of a lymphangiosclerosis. The connective tissue/smooth muscle gradient increased from decade to decade with a slighter progression in groups with higher age A significant increase of lymphangi osclerosis was noted in cases with right heart insufficiency in correlation to the degree of heart insuffiency. Severe lymphangiosclerotic alterations were developed after radical mastectomy and radiotherapy of the axilla, after radiotherapy of other malignant tumors, and in cases with heart failures or vascular dysplasia. Morphometric investigations were not possible in cases with floride lymphangitis and in one case of general vascular amyloidosis.
对94例尸检病例（42例女性，52例男性）的腋窝淋巴管进行了连续切片组织学研究。在近8000次单独测量中，测量了淋巴管的总直径、血管壁直径、内侧结缔组织直径，最后测量了人工组织间隙的直径。借助计算机对不同血管壁成分的计数平均值进行了统计学评估。由于淋巴管系统中数量和大小的个体差异巨大，无法对不同壁成分的测量数据进行直接比较。因此，血管中层结缔组织与平滑肌的比例被视为淋巴管硬化发展的一个重要参数。结缔组织/平滑肌梯度随年龄每十年增加，在年龄较大的组中进展较缓。与心力衰竭程度相关，右心功能不全病例中淋巴管硬化显著增加。在根治性乳房切除术和腋窝放疗后、其他恶性肿瘤放疗后以及心力衰竭或血管发育异常的病例中，出现了严重的淋巴管硬化改变。在有 floride 淋巴管炎的病例和一例全身性血管淀粉样变性病例中无法进行形态计量学研究。
