Kühne R, Franke R, Sprinz H, Hübner G
Acta Biol Med Ger. 1979;38(10):1441-6.
Studies of protein binding in homologous series of drugs are of great interest for drug research. Apparent binding constants of phenoxyacetic and phenylacetic acids to horseradish peroxidase and to human serum albumin are evaluated by NMR studies and an optical method. These constants are good parameters to describe hydrophobic interactions, and the results are in a good agreement with our protein binding model described previously.
对药物研究而言，关于同系列药物中蛋白质结合的研究极具意义。通过核磁共振研究和一种光学方法评估了苯氧乙酸和苯乙酸与辣根过氧化物酶及人血清白蛋白的表观结合常数。这些常数是描述疏水相互作用的良好参数，且结果与我们之前描述的蛋白质结合模型高度吻合。
