Michel A, Gudim V, Scigalla P, Iwanowna V C, Gross J
Acta Biol Med Ger. 1979;38(10):1479-84.
In the present study, hematocrit, pO2 in the capillary blood, reticulocyte count, erythropoietin activity in plasma and activity of the erythropoiesis inhibition factor in 24-h collective urine were determined in newborns and infants with cyanotic malformations of the heart (transpositions of the big arteries). The plasma of the healthy newborns shows immediately after birth an erythropoietin activity below 1%, as measured by the 59Fe incorporation. The erythropoietin activity of the plasma of infants with cyanotic malformations of the heart is enhanced up to the 14th day of life. In the period of day 14--30 it corresponds to the values of healthy newborns despite the persistence of hypoxia. After the 30th day of life there is again demonstrable an increased erythropoietin activity in the plasma of infants with cyanotic malformations of the heart. Obviously, the low values of 59Fe incorporation from day 14--30 are due to the occurrence of the erythropoiesis inhibition factor. In the urine of infants with cyanotic malformations of the heart there could be demonstrated distinct inhibitions of the stimulated erythropoiesis of the polycythemic mouse. The present studies suggest that the erythropoiesis inhibition factor occurs in postnatal development irrespectively of the degrees of O2-supply of the tissue, and is possibly dependent on the gestational age.
在本研究中，对患有紫绀型心脏畸形（大动脉转位）的新生儿和婴儿，测定了血细胞比容、毛细血管血中的氧分压、网织红细胞计数、血浆中的促红细胞生成素活性以及24小时收集尿液中的红细胞生成抑制因子活性。通过59Fe掺入法测定，健康新生儿出生后血浆中的促红细胞生成素活性立即低于1%。患有紫绀型心脏畸形的婴儿血浆中的促红细胞生成素活性在出生后第14天之前升高。在第14至30天期间，尽管存在持续性缺氧，但其与健康新生儿的值相当。出生后第30天之后，患有紫绀型心脏畸形的婴儿血浆中的促红细胞生成素活性再次明显升高。显然，第14至30天59Fe掺入值较低是由于红细胞生成抑制因子的出现。在患有紫绀型心脏畸形的婴儿尿液中，可以证明对多血质小鼠受刺激的红细胞生成有明显抑制作用。目前的研究表明，红细胞生成抑制因子在出生后的发育过程中出现，与组织的氧气供应程度无关，并且可能取决于胎龄。
