The comparative influence of gamma-hydroxy butyric acid, althesin and etomidate on the neuromuscular blocking potency of pancuronium in man.

The potentiating effect of gamma-hydroxy butyric acid (GHB), Althesin and etomidate on pancuronium was studied in man. GHB proved to influence pancuronium the least whereas Althesin and etomidate potentiate considerably. It is concluded that the amount of non-depolarizing relaxant needed depends on the type of anesthesia given. For neuromuscular blocking studies, GHB and/or thiopentone anesthesia seem to be preferable.