Green M, Silverman I, Suffet F, Taleporos E, Turkel W V
Am J Drug Alcohol Abuse. 1979;6(4):413-29. doi: 10.3109/00952997909007053.
This study reports pregnancy outcomes for 105 addicted women enrolled in New York Medical College's Pregnant Addicts and Addicted Mothers Program. Three classes of variables are examined: prenatal care variables, obstetrical outcomes, and neonatal outcomes. As a first step, percentage distributions are shown for all variables within each class. With respect to the second and third classes, comparisons are made when possible to findings reported elsewhere on heroin-addicted, methadone-maintained, and drug-free populations. Zero-order correlations are then shown for the prenatal care variables versus the neonatal outcomes. It is found that the mother's number of prenatal medical visits correlates significantly with the neonate's gestational age at birth and birth weight, and that her methadone dose at time of delivery correlates significantly with the neonate's withdrawal status. The effect of the prenatal care variables on the two key neonatal outcomes--gestional age at birth and birth weight--is then examined via a stepwise regression analysis. It is found that two of the variables--gestional duration at first prenatal visit and number of prenatal visits--together account for 18.5% of the variance in birth weight and 26.9% of the variance in gestational age at birth, while maternal methadone dose has virtually no effect on these outcome measures. The findings indicate that better neonatal outcomes are associated with the mother's joining the program relatively early in pregnancy and coming in relatively often for prenatal care.
本研究报告了纽约医学院“孕期成瘾者及成瘾母亲项目”中105名成瘾女性的妊娠结局。研究考察了三类变量:产前护理变量、产科结局和新生儿结局。第一步,展示了每类变量中所有变量的百分比分布。对于第二类和第三类变量,尽可能与其他地方报道的海洛因成瘾者、美沙酮维持治疗者及无药物成瘾者群体的研究结果进行比较。然后展示了产前护理变量与新生儿结局之间的零阶相关性。研究发现,母亲的产前就诊次数与新生儿的出生孕周和出生体重显著相关,且她分娩时的美沙酮剂量与新生儿的戒断状态显著相关。随后通过逐步回归分析考察了产前护理变量对两个关键新生儿结局——出生孕周和出生体重——的影响。研究发现,其中两个变量——首次产前检查时的孕周和产前就诊次数——共同解释了出生体重方差的18.5%以及出生孕周方差的26.9%,而母亲的美沙酮剂量对这些结局指标几乎没有影响。研究结果表明,更好的新生儿结局与母亲在孕期相对较早加入该项目并相对频繁地进行产前护理有关。