Drózdz M, Kucharz E, Wieczorek M
Arch Immunol Ther Exp (Warsz). 1979;27(6):889-98.
Morphological studies of the heart muscle were carried out in healthy rats as well as treated with hydralazine or binazine after administration of adrenaline, noradrenaline, isoprenaline, regitine or propranolol. Hydrazinophtalazines (25 mg/kg body wt, daily) were given during 7 months. After discontinuation of this treatment the drugs were administered during 15 days. Evident changes (e.g. inflammatory infiltrations, focal necrosis and fibrosis) were found after administration of noradrenaline, adrenaline or isoprenaline. No differences were found in the reactivity to catecholamines in healthy and hydrazinophtalazine-treated rats.
对健康大鼠以及在给予肾上腺素、去甲肾上腺素、异丙肾上腺素、酚妥拉明或普萘洛尔后用肼屈嗪或二氮嗪处理的大鼠进行了心肌形态学研究。肼酞嗪（25毫克/千克体重，每日）连续给予7个月。停止这种治疗后，在15天内给予这些药物。在给予去甲肾上腺素、肾上腺素或异丙肾上腺素后发现了明显变化（如炎症浸润、局灶性坏死和纤维化）。在健康大鼠和经肼酞嗪处理的大鼠中，对儿茶酚胺的反应性未发现差异。
