N-乙酰葡糖胺的（1-4）-和（1-5）-内酯对N-乙酰-β-D-氨基葡萄糖苷酶的抑制作用。
The inhibition of N-acetyl-beta-D-glucosaminase by the (1-4)-and (1-5)-lactones of N-acetylglucosaminic acid.
作者信息
Couling T E, Goodey R
出版信息
Biochem J. 1970 Sep;119(2):303-6. doi: 10.1042/bj1190303.
Abstract
The inhibition of N-acetyl-beta-d-glucosaminase activity by 2-acetamido-2-deoxy-d-gluconolactone was examined. Separation of the (1-->4)- and (1-->5)-lactones was achieved by using paper chromatography or countercurrent distribution and identification was obtained by examination of the relative stability of the components of separated material. Quantitative measurement of the two lactones was by kinetic titration or by a colorimetric method based on their reaction with hydroxylamine. It was shown that only the (1-->5)-lactone acted as an inhibitor of N-acetyl-beta-d-glucosaminase.
摘要
研究了2-乙酰氨基-2-脱氧-D-葡糖酸内酯对N-乙酰-β-D-氨基葡萄糖苷酶活性的抑制作用。通过纸色谱法或逆流分配法实现了(1→4)-和(1→5)-内酯的分离，并通过检查分离物质各组分的相对稳定性进行了鉴定。两种内酯的定量测定采用动力学滴定法或基于它们与羟胺反应的比色法。结果表明，只有(1→5)-内酯作为N-乙酰-β-D-氨基葡萄糖苷酶的抑制剂起作用。
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本文引用的文献
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Inhibition of glycosidases by aldonolactones of corresponding configuration: Preparation of (1-->5)-lactones by catalytic oxidation of pyranoses and study of their inhibitory properties.相应构型的 aldonolactones 对糖苷酶的抑制作用：通过吡喃糖的催化氧化制备(1-->5)-内酰胺，并研究其抑制特性。
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Inhibition of glycosidases by aldonolactones of corresponding configuration. 2. Inhibitors of beta-N-acetylglucosaminidase.相应构型的醛糖内酯对糖苷酶的抑制作用。2. β-N-乙酰氨基葡萄糖苷酶的抑制剂。
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Inhibition of glycosidases by aldonolactones of corresponding configuration.相应构型的醛糖内酯对糖苷酶的抑制作用。
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Alpha-mannosidase and other glycosidases in the tissues of the mouse and the rat, with special reference to the sex organs.小鼠和大鼠组织中的α-甘露糖苷酶及其他糖苷酶，特别涉及性器官
Nature. 1956 Dec 29;178(4548):1469-70. doi: 10.1038/1781469a0.
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Inhibition of glycosidases by aldonolactones of corresponding configuration. 4. Inhibitors of mannosidase and glucosidase.相应构型的醛糖内酯对糖苷酶的抑制作用。4. 甘露糖苷酶和葡萄糖苷酶的抑制剂。
Biochem J. 1964 May;91(2):378-84. doi: 10.1042/bj0910378.
8
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