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N-乙酰葡糖胺的（1-4）-和（1-5）-内酯对N-乙酰-β-D-氨基葡萄糖苷酶的抑制作用。

The inhibition of N-acetyl-beta-D-glucosaminase by the (1-4)-and (1-5)-lactones of N-acetylglucosaminic acid.

作者信息

Couling T E, Goodey R

出版信息

Biochem J. 1970 Sep;119(2):303-6. doi: 10.1042/bj1190303.

DOI:10.1042/bj1190303
PMID:5496092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1179353/
Abstract

The inhibition of N-acetyl-beta-d-glucosaminase activity by 2-acetamido-2-deoxy-d-gluconolactone was examined. Separation of the (1-->4)- and (1-->5)-lactones was achieved by using paper chromatography or countercurrent distribution and identification was obtained by examination of the relative stability of the components of separated material. Quantitative measurement of the two lactones was by kinetic titration or by a colorimetric method based on their reaction with hydroxylamine. It was shown that only the (1-->5)-lactone acted as an inhibitor of N-acetyl-beta-d-glucosaminase.

摘要

研究了2-乙酰氨基-2-脱氧-D-葡糖酸内酯对N-乙酰-β-D-氨基葡萄糖苷酶活性的抑制作用。通过纸色谱法或逆流分配法实现了(1→4)-和(1→5)-内酯的分离，并通过检查分离物质各组分的相对稳定性进行了鉴定。两种内酯的定量测定采用动力学滴定法或基于它们与羟胺反应的比色法。结果表明，只有(1→5)-内酯作为N-乙酰-β-D-氨基葡萄糖苷酶的抑制剂起作用。

相似文献

1
The inhibition of N-acetyl-beta-D-glucosaminase by the (1-4)-and (1-5)-lactones of N-acetylglucosaminic acid.N-乙酰葡糖胺的（1-4）-和（1-5）-内酯对N-乙酰-β-D-氨基葡萄糖苷酶的抑制作用。
Biochem J. 1970 Sep;119(2):303-6. doi: 10.1042/bj1190303.
2
On the inhibition of beta-N-acetyl-D-glucosaminidase by 2-acetamido-2-deoxy-D-glucono-(1-5)-lactone.关于2-乙酰氨基-2-脱氧-D-葡萄糖酸-(1-5)-内酯对β-N-乙酰-D-氨基葡萄糖苷酶的抑制作用
Biochem Biophys Res Commun. 1968 Sep 30;32(6):1025-30. doi: 10.1016/0006-291x(68)90132-0.
3
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Carbohydr Res. 1975 Sep;43(2):345-54. doi: 10.1016/s0008-6215(00)83498-9.
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Esterase activities of beta-N-acetyl-D-glucosaminidase preparations.β-N-乙酰-D-葡萄糖胺酶制剂的酯酶活性。
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[Enzymatic isomerization of 2-acetamido-2-deoxy-D-glucono-(1,5)-lactone by N-acetyl-beta-D-glucosamindidase].[N-乙酰-β-D-氨基葡萄糖苷酶催化2-乙酰氨基-2-脱氧-D-葡萄糖酸-(1,5)-内酯的酶促异构化反应]
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Inhibition of glycosidases by aldonolactones of corresponding configuration. The specificity of alpha-L-arabinosidase.相应构型的醛糖内酯对糖苷酶的抑制作用。α-L-阿拉伯糖苷酶的特异性。
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Microheterogeneity of N-acetyl- -D-hexosaminidase of bull epididymis.公牛附睾N-乙酰-β-D-己糖胺酶的微异质性
Proc Soc Exp Biol Med. 1973 Feb;142(2):466-70. doi: 10.3181/00379727-142-37047.
9
[Separation and characteristics of substrate specificity of N-acetyl-beta-D-glucosaminidase from pig epididymis].[猪附睾N-乙酰-β-D-氨基葡萄糖苷酶的分离及其底物特异性特征]
Biokhimiia. 1971 Jan-Feb;36(1):33-42.
10
The inhibitory activity of 2-acetamido-2-deoxy-D-gluconolactones and their isopropylidene derivatives on 2-acetamido-2-deoxy-beta-D-glucosidase.2-乙酰氨基-2-脱氧-D-葡萄糖酸内酯及其异亚丙基衍生物对2-乙酰氨基-2-脱氧-β-D-葡萄糖苷酶的抑制活性。
Carbohydr Res. 1974 Nov;37(2):321-29. doi: 10.1016/s0008-6215(00)82921-3.

本文引用的文献

1
Inhibition of glycosidases by aldonolactones of corresponding configuration: Preparation of (1-->5)-lactones by catalytic oxidation of pyranoses and study of their inhibitory properties.相应构型的 aldonolactones 对糖苷酶的抑制作用：通过吡喃糖的催化氧化制备(1-->5)-内酰胺，并研究其抑制特性。
Biochem J. 1967 Mar;102(3):929-41. doi: 10.1042/bj1020929.
2
The primary oxidation product of enzymatic glucose-6-phosphate oxidation.酶促6-磷酸葡萄糖氧化的主要氧化产物。
J Biol Chem. 1952 Jan;194(1):417-25.
3
Identification of a gluconolactonase.葡糖酸内酯酶的鉴定。
J Biol Chem. 1955 Feb;212(2):677-85.
4
Inhibition of glycosidases by aldonolactones of corresponding configuration. 2. Inhibitors of beta-N-acetylglucosaminidase.相应构型的醛糖内酯对糖苷酶的抑制作用。2. β-N-乙酰氨基葡萄糖苷酶的抑制剂。
Biochem J. 1958 Jul;69(3):467-76. doi: 10.1042/bj0690467.
5
Inhibition of glycosidases by aldonolactones of corresponding configuration.相应构型的醛糖内酯对糖苷酶的抑制作用。
Biochem J. 1957 Feb;65(2):389-95. doi: 10.1042/bj0650389.
6
Alpha-mannosidase and other glycosidases in the tissues of the mouse and the rat, with special reference to the sex organs.小鼠和大鼠组织中的α-甘露糖苷酶及其他糖苷酶，特别涉及性器官
Nature. 1956 Dec 29;178(4548):1469-70. doi: 10.1038/1781469a0.
7
Inhibition of glycosidases by aldonolactones of corresponding configuration. 4. Inhibitors of mannosidase and glucosidase.相应构型的醛糖内酯对糖苷酶的抑制作用。4. 甘露糖苷酶和葡萄糖苷酶的抑制剂。
Biochem J. 1964 May;91(2):378-84. doi: 10.1042/bj0910378.
8
On the inhibition of beta-N-acetyl-D-glucosaminidase by 2-acetamido-2-deoxy-D-glucono-(1-5)-lactone.关于2-乙酰氨基-2-脱氧-D-葡萄糖酸-(1-5)-内酯对β-N-乙酰-D-氨基葡萄糖苷酶的抑制作用
Biochem Biophys Res Commun. 1968 Sep 30;32(6):1025-30. doi: 10.1016/0006-291x(68)90132-0.