接受兔抗人胸腺细胞球蛋白治疗的患者中异种血清γ球蛋白的放射免疫测定。
Radioimmune assay of heterologous serum gamma-globulin in patients receiving rabbit antihuman thymocyte globulin.
作者信息
Bieber C P, Lydick E, Griepp R B, David L A, Oyer P E, Stinson E B
出版信息
Transplantation. 1975 Nov;20(5):393-8. doi: 10.1097/00007890-197511000-00006.
A radioimmune assay (RIA) method for detecting heterologous serum rabbit gamma-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit gamma-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.
本文描述了一种用于检测异种血清兔γ球蛋白（RG）及其抗体的放射免疫分析（RIA）方法。该方法用于监测接受兔抗胸腺细胞球蛋白（RATG）治疗的患者血清中兔球蛋白的水平。在7名接受RATG治疗的心脏移植受者中，最后一剂给药后1 - 3天达到RG血清最高水平。血清水平达到峰值后，4名患者的RG半衰期较短（X = 36小时），3名患者的RG半衰期延长（X = 18天）。仅在那些RG半衰期短的患者中可检测到患者抗兔γ球蛋白抗体。这些患者的抗兔抗体滴度极低，放射免疫分析几乎检测不到。
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