概率筛查模型

Probability screening model.

作者信息

Dmitrieva N V, Nizhnii S V, Piruzyan L A, Polishchuk E S

出版信息

Biol Bull Acad Sci USSR. 1979 Jul-Aug;6(4):423-31.

Abstract

A comparative analysis is given of various types of systems of selecting biologically active substances. A theoretical probability model of tests on chemical compounds for biological activity (screening) has been constructed which permits an evaluation of the efficacy of screening on the basis of fairly reasonable assumptions. It has been shown that this efficacy decreases in time with a fixed number of types of activity taken into consideration and rises sharply with an increase in the number of types of activity of chemical compounds taken into account in the tests.

摘要

对各种筛选生物活性物质的系统进行了比较分析。构建了一个关于化合物生物活性测试（筛选）的理论概率模型，该模型允许在相当合理的假设基础上评估筛选的有效性。结果表明，在考虑的活性类型数量固定的情况下，这种有效性会随时间降低，而在测试中考虑的化合物活性类型数量增加时，有效性会急剧上升。