Khaikyna B J, Kuz'mynska U A, Veremenko L M
Ukr Biokhim Zh. 1975 Jul-Aug;47(4):487-90.
Swelling and contraction of the rat liver mitochondria were studied as affected by chloroorganic pesticides of hexachlorocyclohexane gamma-isomer (gamma-HCCH) and polychlorocamphene (PCC). Administration for two days of gamma-HCCH in a dose of 34 mg/kg and PCC in a dose of 48 mg/kg established to ccause swelling of the liver mitochindria in vivo, a decrease in their ability to swelling in KCl and KH2PO4 and to contraction with addition of ATP. When gamma-HCCH is administered daily for six months in a dose of 1.7 mg/kg the indices under study rise and in case of PCC analogous adninistration in a dose of 2.4 mg/kg-- the drop. The found differince in the effect of the mentioned preparations when they are introduced to the animal organism for a long time might be connected with singularities in their cumulative properties.
研究了六氯环己烷γ异构体（γ-HCCH）和聚氯樟烯（PCC）这两种氯代有机农药对大鼠肝脏线粒体肿胀和收缩的影响。以34mg/kg的剂量给大鼠连续两天施用γ-HCCH，以48mg/kg的剂量施用PCC，结果发现这会导致体内肝脏线粒体肿胀，使其在氯化钾和磷酸二氢钾中肿胀的能力以及添加三磷酸腺苷（ATP）后收缩的能力下降。当以1.7mg/kg的剂量每天给大鼠施用γ-HCCH六个月时，所研究的指标会升高；而当以2.4mg/kg的剂量对大鼠进行类似的PCC施用时，这些指标则会下降。长期将上述制剂引入动物机体时所发现的其效果差异，可能与它们的累积特性的独特性有关。
