钙和镁对肠平滑肌药物反应的影响。
The effects of calcium and magnesium on the response of intestine smooth muscle to drugs.
作者信息
Burgen A S, Spero L
出版信息
Br J Pharmacol. 1970 Nov;40(3):492-500. doi: 10.1111/j.1476-5381.1970.tb10630.x.
Abstract
- The sensitivity of the longitudinal muscle of the guinea-pig ileum to muscarinic drugs producing contraction depends on optimum concentrations of calcium and magnesium. It can also be reduced by changes in sodium concentration and osmolarity.2. The rubidium efflux response to these same drugs is insensitive to any of these changes in the external medium.3. Raised calcium or magnesium concentration has the effect of largely annulling the differences in structure-activity relationships of the two responses as they exist in optimal media.4. The effects are explained in terms of a labile coupling process between a single receptor and the contractile process compared with a stable coupling process of the efflux process.
摘要
豚鼠回肠纵肌对产生收缩作用的毒蕈碱类药物的敏感性取决于钙和镁的最佳浓度。它也会因钠浓度和渗透压的变化而降低。
铷外流对这些相同药物的反应对细胞外介质中的任何这些变化均不敏感。
钙或镁浓度升高的作用是在很大程度上消除两种反应在最佳介质中存在的构效关系差异。
这些效应是根据单一受体与收缩过程之间不稳定的偶联过程来解释的，与之相比，外流过程则是稳定的偶联过程。
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