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Br J Pharmacol. 1970 Nov;40(3):526-7. doi: 10.1111/j.1476-5381.1970.tb10636.x.
2
Influence of thyroxine and its precursors on in vitro lysis of tadpole tail.甲状腺素及其前体对蝌蚪尾部体外溶解的影响。
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Effects of capsaicin desensitization on the stimulatory effect of kinins, prostaglandins, biogenic amines and various drugs in guinea-pig isolated atria.辣椒素脱敏对豚鼠离体心房中激肽、前列腺素、生物胺及各种药物刺激作用的影响。
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Studies of isolated fetal mouse hearts in organ culture. Evidence for a direct effect of triiodothyronine in enhancing cardiac responsiveness to norepinephrine.离体培养的胎鼠心脏研究。三碘甲状腺原氨酸直接增强心脏对去甲肾上腺素反应性的证据。
J Clin Invest. 1972 Oct;51(10):2702-9. doi: 10.1172/JCI107089.

本文引用的文献

1
Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.甲状腺状态对心肌固有收缩特性和能量储备的影响。
J Clin Invest. 1967 Oct;46(10):1669-82. doi: 10.1172/JCI105658.
2
Cardiac failure in the dog as a consequence of exogenous hyperthyroidism.犬因外源性甲状腺功能亢进导致的心衰。
Circ Res. 1967 Feb;20(2):242-52. doi: 10.1161/01.res.20.2.242.
3
Left ventricular myocardial contractile response to aortic constriction in the hyperthyroid guinea pig.甲状腺功能亢进豚鼠左心室心肌对主动脉缩窄的收缩反应
Circ Res. 1968 May;22(5):605-14. doi: 10.1161/01.res.22.5.605.
4
Effects of heart failure, ventricular hypertrophy, and alterations in the thyroid state on the contractility of isolated cardiac muscle.心力衰竭、心室肥大及甲状腺状态改变对离体心肌收缩性的影响。
Ann N Y Acad Sci. 1969 Jan 31;156(1):379-86. doi: 10.1111/j.1749-6632.1969.tb16740.x.

甲状腺素及相关化合物对豚鼠离体左心房的变力作用。

Inotropic effects of thyroxine and related compounds on guinea-pig left atria in vitro.

作者信息

Baird J R, Spilker B A

出版信息

Br J Pharmacol. 1970 Nov;40(3):526-7. doi: 10.1111/j.1476-5381.1970.tb10636.x.

DOI:10.1111/j.1476-5381.1970.tb10636.x
PMID:5497801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703112/
Abstract

Triiodothyronine, diiodothyronine and diiodotyrosine have positive inotropic activity on normal guinea-pig left atria in vitro. The increases produced by triiodothyronine and diiodothyronine are small but their detection shows that the inotropic responses to these agents can be studied in vitro. Thyroxine, thyronine and monoiodotyrosine are inactive. Reserpine pre-treatment reduces the inotropic effect of diiodotyrosine but does not reduce those of triiodothyronine and diiodothyronine.

摘要

三碘甲状腺原氨酸、二碘甲状腺原氨酸和二碘酪氨酸对正常豚鼠离体左心房具有正性肌力活性。三碘甲状腺原氨酸和二碘甲状腺原氨酸产生的增加幅度较小，但它们的可检测性表明，对这些药物的肌力反应可以在体外进行研究。甲状腺素、甲状腺原氨酸和一碘酪氨酸无活性。利血平预处理可降低二碘酪氨酸的肌力作用，但不降低三碘甲状腺原氨酸和二碘甲状腺原氨酸的肌力作用。