甲状腺素及相关化合物对豚鼠离体左心房的变力作用。
Inotropic effects of thyroxine and related compounds on guinea-pig left atria in vitro.
作者信息
Baird J R, Spilker B A
出版信息
Br J Pharmacol. 1970 Nov;40(3):526-7. doi: 10.1111/j.1476-5381.1970.tb10636.x.
Abstract
Triiodothyronine, diiodothyronine and diiodotyrosine have positive inotropic activity on normal guinea-pig left atria in vitro. The increases produced by triiodothyronine and diiodothyronine are small but their detection shows that the inotropic responses to these agents can be studied in vitro. Thyroxine, thyronine and monoiodotyrosine are inactive. Reserpine pre-treatment reduces the inotropic effect of diiodotyrosine but does not reduce those of triiodothyronine and diiodothyronine.
摘要
三碘甲状腺原氨酸、二碘甲状腺原氨酸和二碘酪氨酸对正常豚鼠离体左心房具有正性肌力活性。三碘甲状腺原氨酸和二碘甲状腺原氨酸产生的增加幅度较小，但它们的可检测性表明，对这些药物的肌力反应可以在体外进行研究。甲状腺素、甲状腺原氨酸和一碘酪氨酸无活性。利血平预处理可降低二碘酪氨酸的肌力作用，但不降低三碘甲状腺原氨酸和二碘甲状腺原氨酸的肌力作用。
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