甾体类物质对离体大鼠心脏中儿茶酚胺摄取-2的抑制作用。
Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart.
作者信息
Iversen L L, Salt P J
出版信息
Br J Pharmacol. 1970 Nov;40(3):528-30. doi: 10.1111/j.1476-5381.1970.tb10637.x.
Abstract
Various steroids (17-beta-oestradiol, corticosterone, deoxycorticosterone, progesterone, testosterone and androsterone) produced a dose-dependent inhibition of the uptake of (3)H-noradrenaline by the Uptake(2) mechanism in the isolated perfused heart. It is suggested that these results may explain the potentiating effects of such steroids on the responses of vascular smooth muscle to catecholamines.
摘要
多种类固醇（17-β-雌二醇、皮质酮、脱氧皮质酮、孕酮、睾酮和雄酮）对离体灌注心脏中通过摄取（2）机制摄取的（3）H-去甲肾上腺素产生剂量依赖性抑制作用。有人认为，这些结果可能解释了此类类固醇对血管平滑肌对儿茶酚胺反应的增强作用。
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