Shustval N F
Vopr Med Khim. 1975 May-Jun;21(3):235-9.
In patients with coronary atherosclerosis in I and III stages content of histamine in blood, excretion of free histamine with urine, activities of serum histidine decarboxylase and diaminooxidase, histaminopexy of blood serum and content of antihistamine factor were studied. In patients with the disease of the I stage during the attacks of stenocardia content of histamine in blood, the activity of diaminooxidase and content of degranulated basophils were increased, but the histidine decarboxylase activity, histaminopexy, content of antihistamine factor and excretion of free histamine with urine were normal. During the stenocardia attacks in patients with coronary atherosclerosis of the III stage content of degranulated basophils, the histidine decarboxylase activity were increased, histaminopexy and titres of antihistamine factor were decreased. Between the content of histamine in blood and the diaminooxidase activity no correlation was observed. This lack of correlation could cause development of hyperhistaminaemia and increased excretion of free histamine with urine. Antihistamine and desensitizing preparations (pipolphen, heparin, amidopyrine and ascorbic acid) increased the therapeutic efficiency of vasodilating drugs, decreased stenocardia attacks, accelerated both clinical improvement and normalization of histamine metabolism.
对处于I期和III期冠状动脉粥样硬化患者的血液组胺含量、尿游离组胺排泄量、血清组氨酸脱羧酶和二胺氧化酶活性、血清组胺结合力及抗组胺因子含量进行了研究。I期患者在心绞痛发作时，血液组胺含量、二胺氧化酶活性及嗜碱性粒细胞脱颗粒含量增加，但组氨酸脱羧酶活性、组胺结合力、抗组胺因子含量及尿游离组胺排泄量均正常。III期冠状动脉粥样硬化患者在心绞痛发作时，嗜碱性粒细胞脱颗粒含量、组氨酸脱羧酶活性增加，组胺结合力及抗组胺因子滴度降低。血液组胺含量与二胺氧化酶活性之间未观察到相关性。这种缺乏相关性可能导致高组胺血症的发生及尿游离组胺排泄增加。抗组胺和脱敏制剂（苯海拉明、肝素、氨基比林和抗坏血酸）提高了血管扩张药物的治疗效果，减少了心绞痛发作，加速了临床改善及组胺代谢的正常化。
