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[狂犬病组病毒不同毒株的抗原关系研究]

[Study of the antigenic relationship of different strains of the rabies group viruses].

作者信息

Shubladze A K, Bychkova E N

出版信息

Vopr Virusol. 1975 Sep-Oct(5):571-4.

PMID:54997
Abstract

In neutralization tests in animals close antigenic relationship between human virus of acute encephalomyelitis (AEM) and viruses (297 and 598 SG strains) isolated from wild rodents in Czechoslovakia was first established. At the same time, poor antigenic relationship of human AEM virus to viruses isolated in Africa from bats (Lagos bat) and from shrews (YbAn 27377) was demonstrated. Certain differences in the antigenic properties of viruses isolated in Africa and in Czechoslovakia were found. These studies indicate the existence of many varieties in the rabies virus group. Ferther accumulation of data concerning different viruses of the rabies group is necessary as they may be helpful for elucidation of the pathology of certain neuroinfections due to viruses of this group as well as for creation of the necessary collection of the investigated strains for preparation of rabies vaccines.

摘要

在动物中和试验中,首次证实了人类急性脑脊髓炎病毒(AEM)与从捷克斯洛伐克野生啮齿动物中分离出的病毒(297和598 SG株)之间存在密切的抗原关系。同时,还证明了人类AEM病毒与从非洲蝙蝠(拉各斯蝙蝠)和鼩鼱(YbAn 27377)中分离出的病毒的抗原关系较弱。发现了在非洲和捷克斯洛伐克分离出的病毒在抗原特性上存在某些差异。这些研究表明狂犬病病毒组中存在许多变种。有必要进一步积累有关狂犬病组不同病毒的数据,因为它们可能有助于阐明该组病毒引起的某些神经感染的病理学,以及有助于创建用于制备狂犬病疫苗的必要研究菌株库。

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1
[Study of the antigenic relationship of different strains of the rabies group viruses].[狂犬病组病毒不同毒株的抗原关系研究]
Vopr Virusol. 1975 Sep-Oct(5):571-4.
2
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[Antigenic determination of human anti-rabies vaccine against viral street strains common in the wild animal population in Poland].[针对波兰野生动物群体中常见的狂犬病病毒街毒株的人用狂犬病疫苗抗原性测定]
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Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein.杂交瘤单克隆抗体在检测狂犬病病毒与狂犬病相关病毒蛋白抗原差异中的应用。II. 糖蛋白。
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