King A, Davies P, Lawrie A
Ministry of Agriculture, Fisheries and Food Central Veterinary Laboratory, New Haw, Weybridge, Surrey, Great Britain.
Vet Microbiol. 1990 Jun;23(1-4):165-74. doi: 10.1016/0378-1135(90)90146-m.
In the 1930s rabies was shown to affect blood-, insect- and fruit-eating bats. We have prepared anti-nucleocapsid monoclonal antibodies (MAbs) using Mokola and bat (Lagos, Duvenhage and Denmark) rabies viruses as immunogens. With these MAbs we have examined rabies viruses from vampire, insectivorous and frugivorous bats from the Americas, Africa, Europe and the Soviet Union and have compared them with isolates from terrestrial species including man. As well as confirming the findings of others with viruses of African and American bat origin, the results revealed the presence of a second biotype in European bats and demonstrated the presence of serotype 1 as well as serotype 4 viruses in bats of the Soviet Union.
20世纪30年代,狂犬病被证实会感染食血、食虫和食果蝙蝠。我们以莫科拉病毒以及蝙蝠(拉各斯病毒、杜文黑格病毒和丹麦病毒)狂犬病病毒作为免疫原,制备了抗核衣壳单克隆抗体(MAb)。利用这些单克隆抗体,我们检测了来自美洲、非洲、欧洲和苏联的吸血蝙蝠、食虫蝙蝠和食果蝙蝠身上的狂犬病病毒,并将它们与包括人类在内的陆生动物的病毒分离株进行了比较。这些结果不仅证实了其他人对源自非洲和美洲蝙蝠的病毒的研究发现,还揭示了欧洲蝙蝠中存在第二种生物型,并证明了苏联蝙蝠中存在血清型1和血清型4病毒。