甲状腺素在大鼠体内组织结合的持久性
The permanence of tissue binding of thyroxine in the rat.
作者信息
Harland W A, Orr J S
出版信息
J Physiol. 1970 May;207(3):557-61. doi: 10.1113/jphysiol.1970.sp009080.
Abstract
- Male rats were given radiothyroxine and after 24 hr, approximately half the blood volume was replaced by exchange transfusion.2. Plasma concentration of radiothyroxine 2 hr after exchange averaged 81.1% of the value before exchange. This compared with a predicted mean of 97.1% assuming a free and rapid exchange of thyroxine throughout the thyroxine distribution space. The difference between the observed and expected value was highly significant.3. The effective exchangeable pool of thyroxine was found to be approximately twice the plasma volume.4. From these and other observations it is suggested that the liver and plasma constitute most of the exchangeable pool of thyroxine.5. This experiment supports a model of thyroxine metabolism which envisages essentially permanent binding of thyroxine by tissues other than the liver.
摘要
给雄性大鼠注射放射性甲状腺素，24小时后，通过换血置换约一半的血容量。
换血后2小时，放射性甲状腺素的血浆浓度平均为换血前值的81.1%。相比之下，假设甲状腺素在整个甲状腺素分布空间中自由快速交换，预测平均值为97.1%。观察值与预期值之间的差异非常显著。
发现甲状腺素的有效可交换池约为血浆体积的两倍。
从这些以及其他观察结果表明，肝脏和血浆构成了甲状腺素的大部分可交换池。
该实验支持一种甲状腺素代谢模型，该模型设想甲状腺素除肝脏外被其他组织基本永久性结合。
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引用本文的文献
1
An examination of the extent of reversibility of thyroxine binding within the thyroxine distribution space in the rabbit.对家兔甲状腺素分布空间内甲状腺素结合可逆程度的研究。
J Physiol. 1971 Jan;212(2):447-54. doi: 10.1113/jphysiol.1971.sp009334.
本文引用的文献
1
Simultaneous estimation of rates of thyroxine degradation and thyroid hormone synthesis.甲状腺素降解率与甲状腺激素合成率的同步评估。
J Clin Invest. 1955 Jun;34(6):808-19. doi: 10.1172/JCI103136.
2
The interaction of thyroid hormones and protein in biological fluids.甲状腺激素与生物体液中蛋白质的相互作用。
Recent Prog Horm Res. 1957;13:161-202; discussion 202-8.
3
Further studies of the metabolism of thyroxine and 3,5,3'-triiodothyronine in the guinea-pig.豚鼠体内甲状腺素和3,5,3'-三碘甲状腺原氨酸代谢的进一步研究。
J Physiol. 1967 Jul;191(1):167-76. doi: 10.1113/jphysiol.1967.sp008243.
4
Direct measurement of hepatic thyroxine flux in normal man.正常人体内肝脏甲状腺素通量的直接测量。
J Clin Endocrinol Metab. 1968 Oct;28(10):1503-7. doi: 10.1210/jcem-28-10-1503.
5
A model of thyroxine metabolism based on the effects of environmental temperature.基于环境温度影响的甲状腺素代谢模型。
J Physiol. 1969 Feb;200(2):297-310. doi: 10.1113/jphysiol.1969.sp008694.
6
The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin.人体中¹³¹I标记的L-甲状腺素在血浆和肝脏之间的分布动力学：对血清甲状腺素结合球蛋白正常和降低的受试者的观察。
J Clin Invest. 1966 Jun;45(6):939-49. doi: 10.1172/JCI105409.
7
Thyroxine in blood and tissues.血液和组织中的甲状腺素。
Lancet. 1969 Jun 14;1(7607):1210. doi: 10.1016/s0140-6736(69)92187-4.
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