Basu R, Chatterjee A
Prostaglandins Med. 1979 Nov;3(5):291-4. doi: 10.1016/0161-4630(79)90070-3.
Indomethacin at a dose of 2.5 mg/kg from day 18 through day 20 of pregnancy was found to extend the duration of gestation for 2-3 days over the control value. Conversely, prostaglandin F2 alpha (PGF2 alpha) at a dose of 2.0 mg/kg on day 18 of pregnancy induced premature parturition. PGF2 alpha given concurrently with indomethacin resulted in neutralisation of the drug action and the animals delivered viable pups as identically recorded in controls. Failure of indomethacin to extend the length of pseudopregnancy in either bilaterally hysterectomized or bilaterally decidualized pseudopregnant rats revealed that the lengthening of the duration of pregnancy caused by indomethacin is not due to an extension of luteal span, but results from relaxation of the uterine smooth musculature.
在妊娠第18天至第20天，给予剂量为2.5毫克/千克的吲哚美辛，发现其可使妊娠期延长2至3天，超过对照组数值。相反，在妊娠第18天给予剂量为2.0毫克/千克的前列腺素F2α（PGF2α）会诱发早产。PGF2α与吲哚美辛同时给药导致药物作用被中和，动物产下存活幼崽，与对照组记录相同。在双侧子宫切除或双侧蜕膜化假孕大鼠中，吲哚美辛均未能延长假孕长度，这表明吲哚美辛导致妊娠期延长并非由于黄体期延长，而是子宫平滑肌松弛所致。
