Askevold F, Heiberg A
Psychother Psychosom. 1979;32(1-4):223-8. doi: 10.1159/000287391.
Two female monozygous twin pairs discordant for anorexia nervosa are reported, and literature reports on 18 other monozygous pairs are reviewed. Four of the reported pairs are inadequately described and there is doubt about the diagnosis. When the 2 pairs reported here are included, 16 pairs remain: l (38%) were concordant and 10 discordant. Only 3 pairs fulfilled rigorous criteria for anorexia nervosa and zygosity and one of the pairs was concordant. The population prevalence is probably about 2 promille for hospitalized cases, and there is a 6% risk for female sibs of anorectic probands. Hence, if about 1/3 of monozygotic pairs are in fact concordant, a role of genetic factors in the etiology may be suggested.
本文报告了两对患神经性厌食症的女性同卵双胞胎，其中一对患病，一对未患病，并对文献中报道的另外18对同卵双胞胎进行了综述。所报道的18对中有4对描述不充分，诊断存疑。若将本文报道的2对纳入，则还剩16对：其中1对（38%）为一致型，10对为不一致型。只有3对符合神经性厌食症及同卵性的严格标准，其中一对为一致型。住院病例的人群患病率约为2‰，神经性厌食症先证者的女性同胞有6%的患病风险。因此，如果约1/3的同卵双胞胎实际上是一致型，那么可能提示遗传因素在病因学中起作用。
