Lahnborg G, Bergström K
Acta Chir Scand. 1975;141(7):590-5.
In a study of 112 patients undergoing elective major surgery clinical and haemostatic data was followed in connection with a double-blind investigation on the effect of subcutaneous low-dose heparin prophylaxis. None of the patients developed severe thromboembolism but according to lung photoscanning and leg scanning 41 of the patients had deep vein thrombosis and/or pulmonary embolism. Clinically thromboembolism appeared within 4 days after operation. In 22 patients with epidural anaesthesia the incidence of thromboembolism was lower than in the patients with general anaesthesia. The extension of the operation was positively correlated to a higher incidence of thromboembolism. The surgical trauma was reflected in most of the routine haemostatic laboratory parameters, hiding possible minor changes caused by subclinical thromboembolic complications. The low doses of heparin could only be detected with more sensitive methods. A comparison of sodium and calcium heparin administered subcutaneously revealed no significant differences.
在一项针对112例接受择期大手术患者的研究中，结合皮下低剂量肝素预防效果的双盲调查，对临床和止血数据进行了跟踪。没有患者发生严重血栓栓塞，但根据肺部光扫描和腿部扫描，41例患者患有深静脉血栓形成和/或肺栓塞。临床血栓栓塞在术后4天内出现。在22例接受硬膜外麻醉的患者中，血栓栓塞的发生率低于全身麻醉患者。手术范围与血栓栓塞发生率较高呈正相关。手术创伤反映在大多数常规止血实验室参数中，掩盖了由亚临床血栓栓塞并发症引起的可能的微小变化。低剂量肝素只能用更灵敏的方法检测到。皮下注射肝素钠和钙的比较显示无显著差异。
