纤维蛋白溶解活性及125I-纤维蛋白原存活的药理学增强作用。
Pharmacological enhancement of fibrinolytic activity and 125I-fibrinogen survival.
作者信息
Hickman J A
出版信息
J Clin Pathol. 1970 Dec;23(9):797-800. doi: 10.1136/jcp.23.9.797.
Abstract
Studies with (125)I-fibrinogen after the administration of phenformin plus ethyloestrenol in five subjects showed no evidence of enhanced catabolism of fibrinogen despite a fall in plasma fibrinogen concentration and shortened clot lysis time. It seems probable that the fall in plasma fibrinogen concentration after the administration of these drugs is related to diminished hepatic synthesis of fibrinogen and is independent of the induction of plasminogen activator release.
摘要
对五名受试者给予苯乙双胍加乙基雌烯醇后进行的（125）I-纤维蛋白原研究表明，尽管血浆纤维蛋白原浓度下降且凝血块溶解时间缩短，但未发现纤维蛋白原分解代谢增强的证据。这些药物给药后血浆纤维蛋白原浓度下降似乎与肝脏纤维蛋白原合成减少有关，且与纤溶酶原激活物释放的诱导无关。
相似文献
1
Pharmacological enhancement of fibrinolytic activity and 125I-fibrinogen survival.纤维蛋白溶解活性及125I-纤维蛋白原存活的药理学增强作用。
J Clin Pathol. 1970 Dec;23(9):797-800. doi: 10.1136/jcp.23.9.797.
2
Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic systems.苯乙双胍与乙基雌烯醇联合治疗对凝血和纤溶系统的影响。
J Clin Pathol. 1972 Jul;25(7):638-9. doi: 10.1136/jcp.25.7.638.
3
Effect of phenformin and ethyloestrenol on blood fibrinolytic activity on rabbits maintained on high cholesterol diet.苯乙双胍和乙基去甲睾酮对高胆固醇饮食家兔血液纤溶活性的影响。
Indian J Med Res. 1976 Jun;64(6):915-22.
4
Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic systems.苯乙双胍与乙基雌烯醇联合治疗对凝血和纤溶系统的影响。
Scand J Haematol. 1970;7(5):404-8. doi: 10.1111/j.1600-0609.1970.tb01922.x.
5
Mode of action of phenformin plus ethyloestrenol on fibrinolysis.苯乙双胍加乙基雌烯醇对纤维蛋白溶解的作用方式。
Lancet. 1971 Apr 10;1(7702):723-5. doi: 10.1016/s0140-6736(71)91989-1.
6
Pharmacological stimulation of fibrinolytic activity in the surgical patient.
Lancet. 1971 Apr 17;1(7703):774-6. doi: 10.1016/s0140-6736(71)91215-3.
7
Pharmacological enhancement of fibrinolysis.纤维蛋白溶解的药理学增强。
J Clin Pathol. 1969 May;22(3):368-9. doi: 10.1136/jcp.22.3.368-b.
8
[Effects of a combined therapy with ethylestrenol and phenformin on fibrinolysis of selected patients before, during and after surgery].[炔雌醇与苯乙双胍联合疗法对部分患者手术前、手术中和手术后纤溶的影响]
Z Ernahrungswiss Suppl. 1972;12:Suppl 12:52-7.
9
Phenformin plus ethyloestrenol in survivors of myocardial infarction. Three-year pilot study.苯乙双胍加乙基雌烯醇用于心肌梗死幸存者：三年试点研究
Lancet. 1972 Sep 16;2(7777):556-9. doi: 10.1016/s0140-6736(72)91956-3.
10
Phenformin and ethyloestrenol for Raynaud's disease.苯乙双胍和乙基雌烯醇治疗雷诺氏病。
Lancet. 1969 Oct 25;2(7626):906-7. doi: 10.1016/s0140-6736(69)92364-2.
引用本文的文献
1
Behaviour of commercially prepared I-125 fibrinogen in metabolic studies.商业制备的 I-125 纤维蛋白原在代谢研究中的行为。
J Clin Pathol. 1975 Jun;28(6):487-93. doi: 10.1136/jcp.28.6.487.
本文引用的文献
1
MEASUREMENT OF SPONTANEOUS FIBRINOLYTIC ACTIVITY.自发性纤溶活性的测定
J Clin Pathol. 1964 May;17(3):307-9. doi: 10.1136/jcp.17.3.307.
2
Studies of the metabolism and distribution of fibrinogen in healthy men with autologous 125-I-labeled fibrinogen.对健康男性使用自体125-I标记纤维蛋白原进行纤维蛋白原代谢和分布的研究。
J Clin Invest. 1966 Jan;45(1):103-11. doi: 10.1172/JCI105314.
3
Fibrinogen catabolism in microangiopathic haemolytic anaemia.微血管病性溶血性贫血中的纤维蛋白原分解代谢
Br J Haematol. 1968 Jun;14(6):617-25. doi: 10.1111/j.1365-2141.1968.tb00368.x.
4
In vivo behaviour of frozen and freeze-dried fibrinogen and of that prepared from out-dated blood.冷冻及冻干纤维蛋白原以及由过期血液制备的纤维蛋白原的体内行为。
Biochim Biophys Acta. 1969 May;181(1):287-94. doi: 10.1016/0005-2795(69)90251-7.
5
6
Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo.
Lancet. 1969 May 3;1(7601):910-4. doi: 10.1016/s0140-6736(69)92545-8.
7
Fibrinolytic treatment of rheumatoid arthritis with phenformin plus ethyloestrenol.
Lancet. 1966 Oct 8;2(7467):757-61. doi: 10.1016/s0140-6736(66)90360-6.
Zotero 插件