Hickman J A
J Clin Pathol. 1970 Dec;23(9):797-800. doi: 10.1136/jcp.23.9.797.
Studies with (125)I-fibrinogen after the administration of phenformin plus ethyloestrenol in five subjects showed no evidence of enhanced catabolism of fibrinogen despite a fall in plasma fibrinogen concentration and shortened clot lysis time. It seems probable that the fall in plasma fibrinogen concentration after the administration of these drugs is related to diminished hepatic synthesis of fibrinogen and is independent of the induction of plasminogen activator release.
对五名受试者给予苯乙双胍加乙基雌烯醇后进行的（125）I-纤维蛋白原研究表明，尽管血浆纤维蛋白原浓度下降且凝血块溶解时间缩短，但未发现纤维蛋白原分解代谢增强的证据。这些药物给药后血浆纤维蛋白原浓度下降似乎与肝脏纤维蛋白原合成减少有关，且与纤溶酶原激活物释放的诱导无关。
