van Hoorn-Hickman R, van Hoorn W A
S Afr Med J. 1979 Dec 22;56(26):1134--6.
Hyperglucagonaemia after portacaval shunt may be the result of liver dysfunction because of devascularization, or portal diversion. In order to investigate the effects of devascularization, a comparison was made between a group of young pigs which had undergone a portacaval shunt (PCS) alone and a group in which the portal stump had been revascularized from the splenic artery (PCS-R). Plasma glucagon levels were elevated threefold within 4 days of the operation in PCS pigs and after 8 days in PCS-R pigs. Plasma insulin levels were higher in PCS animals on day 3, but thereafter there was no difference. These studies suggest that plasma glucagon levels rose, despite the improvement of liver function by portal arterialization, confirming the hypothesis that the hyperglucagonaemia which follows portacaval shunt is caused by hypersecretion.
门腔分流术后高胰高血糖素血症可能是由于去血管化或门静脉分流导致肝功能障碍所致。为了研究去血管化的影响，对一组仅接受门腔分流术（PCS）的幼猪和一组门静脉残端通过脾动脉进行血管重建的幼猪（PCS-R）进行了比较。PCS猪术后4天内血浆胰高血糖素水平升高了三倍，PCS-R猪术后8天血浆胰高血糖素水平升高。PCS动物在第3天血浆胰岛素水平较高，但此后没有差异。这些研究表明，尽管门静脉动脉化改善了肝功能，但血浆胰高血糖素水平仍升高，证实了门腔分流术后高胰高血糖素血症是由分泌过多引起的这一假设。
